四黄膏在糖尿病足溃疡中的研究

Study on Sihuang Ointment in diabetic foot ulcer

目的探讨四黄膏在糖尿病足溃疡中的应用效果。方法回顾性分析江西省中西医结合医院2019年3月—2020年5月收治的80例糖尿病足溃疡患者的临床资料,按照治疗方法不同分为对照组(40例)和观察组(40例)。对照组采用甲钴胺片口服治疗,观察组采用四黄膏联合甲钴胺片治疗,5 d为1个疗程,两组均治疗3个疗程。比较两组患者的溃疡创面愈合时间、住院时间、临床总有效率、治疗期间不良反应发生率以及治疗前后的踝肱比(ABI)、趾肱比(TBI)变化。结果观察组患者的溃疡创面愈合时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的临床总有效率(95.00%)高于对照组(70.00%),差异有统计学意义(P<0.05)。两组治疗前的ABI、TBI比较,差异无统计学意义(P>0.05);两组治疗后的ABI、TBI大于治疗前,且观察组治疗后的ABI、TBI大于对照组,差异有统计学意义(P<0.05);两组治疗期间的不良反应发生率比较,差异无统计学意义(P>0.05)。结论四黄膏治疗糖尿病足溃疡可显著缩短患者溃疡创面愈合时间、住院时间,同时显著提高患者的临床总有效率,有效改善患者ABI、TBI水平,安全性高。

Objective To explore the application effect of Sihuang Ointment in diabetic foot ulcer.Methods The clinical data of 80 patients with diabetic foot ulcers treated in Jiangxi Provincial Hospital of Integrated Traditional and Western Medicine from March 2019 to May 2020 were retrospectively analyzed.They were divided into the control group(40 cases)and the observation group(40 cases)according to different treatment methods.The control group was treated with Mecobalamin tablets orally,and the observation group was treated with Sihuang Ointment combined with Mecobalamin tablets.5 days was a course of treatment,and both groups were treated for 3 courses of treatment.The ulcer wound healing time,hospital stay,total clinical effective rate,the incidence of adverse reactions during treatment and the changes of ankle brachial index(ABI)and toe brachial index(TBI)before and after treatment were compared between the two groups.Results The wound healing time and hospital stay of patients in the observation group were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).The total clinical effective rate(95.00%)of the observation group after treatment was significantly higher than that of the control group(70.00%),the difference was statistically significant(P<0.05).There was no statistically significant difference in ABI and TBI between the two groups before treatment(P>0.05).The ABI and TBI of the two groups after treatment were significantly greater than those before treatment,and the ABI and TBI levels of the two groups after treatment of the observation group were significantly greater than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Sihuang Ointment can shorten the healing time and hospital stay of patients with diabetic foot ulcers,and significantly improve the total clinical effective rate of patients.It can effectively improve the level of ABI and TBI,and has high safety.