甲状腺功能亢进症中药专利复方用药特点分析

Analysis on Characteristics of Traditional Chinese Patent Compound for Hyperthyroidism

目的基于中国知网专利数据库和SooPAT专利数据库信息,分析甲状腺功能亢进症中药专利复方用药规律。方法使用中国知网专利数据库、SooPAT专利数据库检索治疗甲状腺功能亢进症的中药专利复方,应用古今医案云平台(V2.2.3)统计中药应用频次,并采用聚类分析、关联分析方法探讨其药物配伍、配对规律。结果共纳入110个治疗甲状腺功能亢进症的中药专利复方。药物属性频次分析显示,药性以苦寒、甘寒为主,多归于肝经、肺经;高频应用前10位的中药为夏枯草、牡蛎、白芍、黄芪、生地黄、海藻、当归、麦冬、玄参、柴胡;关联规则算法共得到常用药对11对,海藻-昆布、海藻-昆布-夏枯草两组药物支持度在15%以上;对用药频次前30位的药物进行聚类分析得到六类组方;复杂网络分析得到26味药物组成的核心网络,夏枯草-牡蛎为最强链接药对,夏枯草-海藻次之。结论甲状腺功能亢进症中药专利复方以散结消瘿为主要治法,佐以清热、软坚、化痰,代表性药物为夏枯草、海藻、昆布、牡蛎。

Objective To analyze the characteristics of traditional Chinese patent compounds for hyperthyroidism base on the China Knowledge Network Infrastructure(CNKI)database and the SooPAT database.Methods Data of traditional Chinese medicine(TCM)patent compounds for hyperthyroidism were searched and screened in CNKI database and the SooPAT database.Frequency counting,cluster analysis and association analysis of TCM were performed using Ancient and Modern Medical Case Cloud Platform(V2.2.3)to mine and reveal the consisting rules and characteristics of these patent compounds.Results 110 TCM patent compounds for hyperthyroidism were enrolled.Drug attribute frequency analysis showed the herbs were predominantly bitter,cold,and sweet in properties,and mainly passed through liver and lung meridian.The top 10 frequent herbs were Xiakucao(Prunellae Spica),Muli(Ostreae Concha),Baishao(Paeoniae Radix Alba),Huangqi(Astragali Radix),Shengdihuang(Rehmanniae Radix),Haizao(Sargassum),Danggui(Angelicae Sinensis Radix),Maidong(Ophiopogonis Radix),Xuanshen(Scrophulariae Radix),Chaihu(Bupleuri Radix).Association analysis revealed 11 pairs of herbs,the combinations of Haizao(Sargassum)-Kunbu(Laminariae Thallus Eckloniae Thallus),Haizao(Sargassum)-Kunbu(Laminariae Thallus Eckloniae Thallus)-Xiakucao(Prunellae Spica)had over 15%support rating.Cluster analysis based on top 30 herbs concluded 6 kinds of formulations.Network analysis generated a core network with 26 herbs,in which Xiakucao(Prunellae Spica)-Muli(Ostreae Concha)has the strongest connection,followed by Xiakucao(Prunellae Spica)-Haizao(Sargassum).Conclusion The main effect of traditional Chinese patent compounds for hyperthyroidism was dispersing goiter and dissipating binds,accompanied with clearing heat,softening hard and resolving phlegm.The primary herb were Xiakucao(Prunellae Spica),Haizao(Sargassum),Kunbu(Laminariae Thallus Eckloniae Thallus),Muli(Ostreae Concha).