复治肺结核患者应用肺泰胶囊的有效性研究

Study on the efficacy of application of Feitai Capsules in the retreatment of pulmonary tuberculosis patients

目的探讨复治肺结核患者应用肺泰胶囊的有效性。方法选取辽宁省朝阳市第四医院2019年1月至2020年1月收治的80例复治肺结核患者作为研究对象,按照随机数字表法分为对照组(40例)与实验组(40例)。对照组采用常规抗结核药物治疗,实验组在常规抗结核药物的基础上增加肺泰胶囊治疗。比较两组的心肺功能指标、血清炎症因子水平和临床疗效。结果实验组治疗后的氧分压、第1秒用力呼气量(FEV1)、用力肺活量(FVC)、FEV1/FVC水平高于对照组,二氧化碳分压、肿瘤坏死因子(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、C-反应蛋白(CRP)水平低于对照组,差异有统计学意义(P<0.05);两组治疗前的氧分压、FEV1、FVC、FEV1/FVC、二氧化碳分压、TNF-α、IL-6、IL-8、CRP水平比较,差异无统计学意义(P>0.05);两组治疗后的氧分压、FEV1、FVC、FEV1/FVC水平均高于治疗前,二氧化碳分压、TNF-α、IL-6、IL-8、CRP水平均低于治疗前,差异有统计学意义(P<0.05);实验组的临床总有效率(90%)高于对照组(70%),差异有统计学意义(P<0.05)。结论肺泰胶囊在治疗复治肺结核患者中的应用效果显著,与常规抗结核药物联合使用可有效改善患者的心肺功能及相关血清指标,值得应用于临床并推广。

Objective To investigate the efficacy of application of Feitai Capsules in the retreatment of pulmonary tuberculosis patients.Methods A total of 80 patients of retreated tuberculosis admitted to the Fourth Hospital of Chaoyang City from January 2019 to January 2020 were selected as the research objects.According to the random number table method,the patients were divided into the control group(40 cases)and the experimental group(40 cases).The control group used routine anti-tuberculosis drug treatment,the experimental group adopted the method of adding Feitai Capsules treatment on the basis of conventional anti-tuberculosis drugs.The index of cardiopulmonary function,serum inflammatory factor levels and clinical efficacy were compared between the two groups.Results The levels of oxygen partial pressure,forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC after treatment in the experimental group were higher than those in the control group,the levels of carbon dioxide partial pressure,tumor necrosis factorα(TNF-α),interleukin 6(IL-6),interleukin 8(IL-8),and C-reactive protein(CRP)after treatment in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant difference in the levels of oxygen partial pressure,FEV1,FVC,FEV1/FVC,carbon dioxide partial pressure,TNF-α,IL-6,IL-8,CRP before treatment in the two groups(P>0.05).The levels of oxygen partial pressure,FEV1,FVC,FEV1/FVC after treatment in the two groups were higher than those before treatment,the levels of partial pressure of carbon dioxide,TNF-α,IL-6,IL-8,and CRP after treatment in the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).The total clinical effective rate of the experimental group(90%)was higher than that of the control group(70%),the difference was statistically significant(P<0.05).Conclusion Feitai Capsules has a significant effect in the treatment of patients with retreatment of pulmonary tuberculosis.Combined use with conventional anti-tuberculosis drugs can effectively improve the cardiopulmonary function and related serum indicators of patients,and it is worthy of clinical application and promotion.