银杏二萜内酯葡胺注射液治疗脑梗死对患者脑血流动力学、脑脊液指标及预后的影响

Effect of Ginkgo Diterpene Lactone Meglumine Injection in Cerebral Infarction on Cerebral Hemodynamics,Cerebrospinal Fluid Indexes and Prognosis

目的:探究银杏二萜内酯葡胺注射液治疗脑梗死对患者脑血流动力学、脑脊液指标及预后的影响。方法:选取2019年3月至2020年2月我院收治的脑梗死患者81例。随机分为观察组(40例)和对照组(41例),对照组给予常规治疗,观察组在常规治疗基础上加用银杏二萜内酯葡胺注射液治疗,治疗14d。观察两组患者治疗前及治疗3个月后脑血流动力学、脑脊液指标、神经功能、日常生活能力、不良反应。结果:治疗后,观察组脑平均血流速度、左侧椎动脉血流量、右侧椎动脉血流量、基底动脉血流量高于对照组(P<0.05);观察组脑脊液中白介素-6、肿瘤坏死因子-α低于对照组(P<0.05);观察组美国国立卫生院卒中量表及改良Rankin量表评分低于对照组,日常生活能力评定量表评分高于对照组(P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:银杏二萜内酯葡胺注射液治疗脑梗死可有效调节患者脑血流动力学与脑脊液指标,发挥脑细胞保护作用,可改善神经功能与日常生活能力,且不良反应较小。

Objective:To explore the effects of ginkgo diterpene lactone meglumine injection on cerebral hemodynamics,cerebrospinal fluid indexes and prognosis in patients with cerebral infarction.Methods:A total of 81 patients with cerebral infarction admitted to our hospital from March 2019 to February 2020 were selected and randomly divided into observation group(40 cases)and control group(41 cases).The control group received conventional treatment,and the observation group was treated with Ginkgo diterpene lactone meglumine injection on the basis of the control group.After treatment for 14 days,cerebral hemodynamics,cerebrospinal fluid indexes,nerve function and activities of daily living,and adverse reactions in the two groups were observed before treatment and 3 months after treatment.Results:After treatment,the average cerebral blood flow velocity,left vertebral artery blood flow,right vertebral artery blood flow,and basilar artery blood flow in the observation group were higher than those in the control group(P<0.05).The levels of interleukin-6 and tumor necrosis factor-αin the cerebrospinal fluid of the observation group were lower than those of the control group(P<0.05).The scores of National Institutes of health medium scale and modified Rankin scale in the observation group were lower than those in the control group,and the score of the ability of daily living rating scale was higher than that of the control group(P<0.05).The total incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:Ginkgo diterpene lactone meglumine injection can effectively regulate cerebral hemodynamics and cerebrospinal fluid indexes in patients with cerebral infarction,protect their brain cells,and also can improve neurological function and ability of daily living with less adverse reactions.