流感病毒相关性脑病/脑炎研究进展

Research progress of influenza virus associated encephalopathy/encephalitis

流感病毒一般引发呼吸道疾病,近年来,流感病毒引起的一些呼吸道外临床表现也逐渐引起人们关注。其中流感病毒相关性脑病/脑炎(IAE)病死率高,是引起流感病毒感染危重病例死亡的重要原因,治愈者通常存在神经系统后遗症。目前国际上对于IAE的认识普遍较少,现从临床表现、流行病学资料、危险因素、分类、治疗、预后与机制研究等方面系统回顾近年来在IAE取得的进展,以期加深对本病的认识。

Influenza virus infection mainly mediates pathology in respiratory tract,but recent years it has drawn widespread attention by its extrapulmonary complications.Among all the complications,influenza associated encephalo-pathy/encephalitis(IAE),which has high morbidity and mortality,is the most lethal one that causes death in critically ill cases,and even those patients who are cured commonly suffer from neurological sequelae.However,there is little knowledge about IAE in the international society.In this paper,the research progress in IAE would be reviewed from such aspects as clinical manifestations,epidemiologic data,risk factors,classification,treatment,prognosis and mechanism,for the purpose of deepening the comprehension of this disease.