线粒体调节NLRP3炎性体活化的研究进展

Advances in mitochondria regulating NLRP3 inflammasome activation

NLRP3炎性体过度活化参与糖尿病、肥胖、痛风、炎症性肠病、恶性肿瘤、感染等多种疾病的发病。明确NLRP3炎性小体的激活机制,是治疗相关疾病的前提。线粒体是真核细胞的能量工厂,但越来越多的研究发现,线粒体参与机体内的免疫调控。线粒体通过产生mtROS、释放mtDNA、作为炎性体成分的停泊位点、调节糖代谢、脂质代谢等机制调控NLRP3炎性体的活化。本文对近年来线粒体调节NLRP3炎性体活化的研究进行总结,以期为临床治疗相关疾病提供新的思路。

The excessive activation of NLRP3 inflammasome plays a critical role in the pathogenesis of diabetes,obesity,uarthritis,inflammatory bowel disease,malignant tumors,infections and so on.Clarifying the activation mechanism of NLRP3 inflammasome is vital to treat related diseases.Mitochondria is the energy factory in eukaryotic cells,however,reports on the mitochondria regulating NLRP3 inflammasome activation have been creeping up.By generating ROS,releasing mtDNA,providing sites for inflammasome gathering,altering glucose and lipid metabolism,mitochondria is important in regulating NLRP3 inflammasome activation.This article summarizes recent advances in mitochondrial regulation of NLRP3 inflammasome activation to provide new ideas forclinical treatment of related diseases.