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重组人生长激素治疗特发性矮小症的效果及对患儿血清胰岛素样生长因子水平的影响

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摘要 目的:探究采用重组人生长激素对特发性矮小症(ISS)患儿进行治疗的效果及对其血清胰岛素样生长因子的影响。方法:选取2019年1月至12月期间在皖南医学院弋矶山医院就诊的50例ISS患儿作为研究对象。为这些患儿均采用重组人生长激素进行6个月的治疗。根据治疗后患儿身高增长的情况将其分为生长激素敏感组和生长激素不敏感组,比较两组患儿的生长速率及治疗前后其血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)的水平。结果:治疗后,本研究中50例ISS患儿血清IGF-1和IGFBP-3的水平均高于治疗前,差异有统计学意义(P<0.05)。治疗后,生长激素敏感组患儿的生长速率快于生长激素不敏感组患儿,其血清IGF-1和IGFBP-3的水平均高于生长激素不敏感组患儿,差异有统计学意义(P<0.05)。结论:采用重组人生长激素对ISS患儿进行治疗可提高其血清胰岛素样生长因子的水平,促进其生长发育。
出处 《当代医药论丛》 2021年第18期53-54,共2页
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