吴茱萸碱类化合物对阿尔茨海默病及脑血管疾病的药理作用研究进展

Research Progress on the Pharmacological Effects of Evodiamine Compounds on Alzheimer’s Disease and Cerebrovascular Disease

吴茱萸碱和去氢吴茱萸碱是中药吴茱萸的主要活性成分,临床研究发现,这两种吴茱萸碱类化合物可通过多条途径减缓阿尔茨海默病的发展进程,此外,吴茱萸碱对脑血管疾病也具有显著疗效.本文综述近年来吴茱萸碱类化合物对阿尔茨海默病和脑血管疾病的药理作用,为临床应用吴茱萸碱和去氢吴茱萸碱治疗阿尔茨海默病和脑血管疾病提供参考.

Evodiamine and dehydroevodiamine are the essential components of chinese traditional medicine Euodia rutaecarpa.Studies have found that these two compounds can slow down the development of Alzheimer’s disease in multiple ways,in addition to the effect of evodiamine on cerebrovascular diseases.This article reviews the pharmacological effects of evodiamine compounds on Alzheimer’s disease and cerebrovascular disease in recent years,providing reference for clinical application of evodiamine and dehydroevodiamine in the treatment of Alzheimer’s disease and cerebrovascular disease.