干扰素诱导蛋白16在儿童传染性单核细胞增多症中的应用价值

Application role of human gamma interferon-induced protein 16 in childhood infectious mononucleosis

目的探讨血清干扰素诱导蛋白16(IFI16)在传染性单核细胞增多症(IM)中的临床价值。方法选取IM患儿73例(IM组),其中20例IM患儿的病程包括急性期和恢复期。以体检健康儿童75名作为正常对照组。检测所有对象的白细胞(WBC)计数、淋巴细胞百分比(LYMPH%)、异型淋巴细胞百分比、淋巴细胞亚群及血清IFI16水平。采用Pearson相关分析评估各项目之间的相关性。结果IM组WBC计数、LYMPH%、异型淋巴细胞百分比及血清IFI16水平均高于正常对照组(P<0.01)。IM患儿急性期血清IFI16水平低于恢复期(P<0.05)。Pearson相关分析结果显示,IM组血清IFI16与LYMPH%、CD4^(+)T细胞百分比及CD4^(+)/CD8^(+)比值呈正相关(r值分别为0.24、0.27、0.29,P<0.05),与异型淋巴细胞百分比、CD3^(+)T细胞百分比、CD8^(+)T细胞百分比、CD19^(+)B细胞百分比及CD16^(+)CD56^(+)自然杀伤细胞无相关性(r值分别为-0.13、-0.18、-0.19、0.12、0.09,P>0.05)。结论血清IFI16水平或可作为IM辅助诊断和预后判断的指标。

Objective To investigate the clinical application value of serum human gamma interferon-induced protein 16(IFI16)in childhood infectious mononucleosis(IM).Methods A total of 73 children with IM(IM group)were recruited,of which 20 children with IM had acute phase and recovery phase.Totally,75 healthy children were enrolled as control group.White blood cell(WBC)count,the percentage of lymphocyte(LYMPH%),the percentage of atypical lymphocyte,lymphocyte subsets and serum levels of IFI16 were determined.Pearson correlation analysis was used to analyze the correlations.Results WBC count,LYMPH%,the percentage of atypical lymphocyte and serum levels of IFI16 in IM group were higher than those in control group(P<0.01).Serum level of IFI16 among IM children in recovery phase was higher than that in acute phase(P<0.05).Serum level of IFI16 in IM group was positively correlated with LYMPH%,the percentage of CD4^(+)T cell and the ratio of CD4^(+)/CD8^(+)(r values were 0.24,0.27 and 0.29,respectively,P<0.05).There was no correlation with the percentage of atypical lymphocyte,the percentage of CD3^(+)T cell,the percentage of CD8^(+)T cell,the percentage of CD19^(+)B cell and the CD16^(+)CD56^(+)natural killer cell(r values were-0.13,-0.18,-0.19,0.12 and 0.09,respectively,P>0.05).Conclusions Serum level of IFI16 may be used for the auxiliary diagnosis and prognosis judgment of IM.