壮骨强筋片对骨质疏松患者腰椎融合术后骨融合的应用效果

The effect of the Zhuanggu Qiangjin tablets on bone fusion after lumbar fusion in patients with osteoporosis

目的:探讨壮骨强筋片对骨质疏松(肝肾亏虚型)患者腰椎融合术后骨融合的应用效果。方法:选择96例骨质疏松(肝肾亏虚型)患者作为研究对象,根据随机数字表法,分为观察组和对照组,各组48例,对照组患者使用常规治疗,观察组患者在常规治疗措施上加以壮骨强筋片治疗,对比两组患者治疗前后下腰痛日本骨科协会评估治疗学会(Japanese Orthopaedic Association,JOA)评分、中医临床症状积分、改良Brantigan评分的变化情况,同时测定两组患者治疗前后血清骨转换标志物水平[I型前胶原氨基端原肽(Procollagen I N-terminal Propeptide,PINP)、I型胶原交联C-端末肽β特殊序列(β-CTX)]变化情况,并比较两组患者的临床疗效。结果:治疗后,观察组的JOA评分、中医临床症状积分、改良Brantigan评分、血清骨转换标志物水平改善程度均明显优于对照组,临床总有效率明显高于对照组,均P<0.05。结论:在骨质疏松(肝肾亏虚型)行腰椎融合术后骨融合患者中施以采取壮骨强筋片治疗,可有效提高临床疗效,调节骨代谢水平。

Objective:To investigate the effect of the Zhuanggu Qiangjin tablets(壮骨强筋片)on bone fusion after lumbar fusion in patients with osteoporosis(liver and kidney deficiency type).Methods:According to the random number table method,96 patients were divided into the observation group and control group,48 cases in each.The control group was given conventional treatment,and the observation group was treated with the Zhuanggu Qiangjin tabletsmore.Results:After treatment,the JOA score,TCM symptom score,modified Brantigan score,and serum bone turnover marker levels in the observation group were significantly better than the control group,and the total efficiency was significantly higher than the control group,all P<0.05.Conclusion:The Zhuanggu Qiangjin tablets on osteoporosis(liver and kidney deficiency type)with bone fusion after lumbar fusion can effectively improve efficacy and regulate bone metabolism.