中药灌肠治疗慢性盆腔炎的疗效及对血液流变学和炎症及氧化应激指标的影响分析

Efficacy of TCM enema on chronic pelvic inflammatory disease and its influence on hemorheology,inflammation and oxidative stress indicators

目的:探讨中药灌肠治疗慢性盆腔炎的疗效及对患者血液流变学、炎性因子、氧化应激指标的影响。方法:以青岛大学医学院附属医院威海医院收治的慢性盆腔炎88例患者为研究对象,收治时间为2019年3月-2020年3月。以抽签法随机分成两组,对照组(44例)常规西医内科治疗,观察组(44例)在对照组基础上增加中药灌肠治疗。对比不同的治疗方案对治疗疗效、血液流变学指标、炎症因子指标、氧化应激指标的影响。方法:两组的治疗总有效率对比差异有统计学意义(P<0.05)。治疗前两组患者中医证候积分、血液流变学指标、炎症因子指标、氧化应激指标的基线资料对比差异无统计学意义(P>0.05)。治疗后中医证候积分水平,血液流变学指标血浆粘度、全血粘度高切、全血粘度低切,炎症因子指标肿瘤坏死因子-α,氧化应激指标丙二醛低于对照组;炎症因子指标白细胞介素-10、白细胞介素-2,氧化应激指标超氧化物歧化酶高于对照组(P<0.05)。结论:在常规西医内科治疗的基础上增加中药灌肠治疗慢性盆腔炎的疗效可显著提升,同时对血液流变学指标、炎症、氧化应激反应均有积极影响。

Objective:To observe efficacy of TCM enema on chronic pelvic inflammatory disease and its influence on hemorheology,inflammation and oxidative stress indicators.Methods:From March 2019 to March 2020,88 were randomly divided into two groups by lottery.The control group(44 cases)was given conventional western medical treatment,and the observation group(44 cases)was given TCM enema treatment on the basis of the control group.Results:The total efficiency between the two groups was significantly different(P<0.05).After treatment,TCM syndrome integration level,blood rheology index plasma viscosity,whole blood viscosity high cut,whole blood low cut,inflammatory factor index TNF-αand MDA in the observation group were lower;IL-10,IL-2,SOD were higher(P<0.05).Conclusion:On the basis of conventional western medical treatment,adding TCM enema to treat chronic pelvic inflammatory disease can significantly improve the curative effect,and at the same time,it has a positive impact on blood rheology indexes,inflammation,and oxidative stress.