糠酸莫米松鼻喷雾剂联合通窍鼻炎片治疗变应性鼻炎的临床疗效观察

Clinical efficacy of mometasone furoate nasal spray with the Tongqiao rhinitis tablets on allergic rhinitis

目的:探究变应性鼻炎患者应用糠酸莫米松鼻喷雾剂联合通窍鼻炎片治疗的临床疗效。方法:73例变应性鼻炎患者以随机数字表法进行分组,分为对照组(36例)与观察组(37例)。对照组仅接受糠酸莫米松鼻喷雾剂治疗,观察组在对照组基础上接受通窍鼻炎片治疗,对两组治疗前后炎症因子水平、免疫功能与复发情况进行观察。结果:治疗前,两组白细胞介素(Interleukin,IL)-4、IL-8与γ干扰素(Interferon-γ,IFN-γ)水平基本一致;治疗后,两组IL-4、 IL-8水平低于治疗前,IFN-γ高于治疗前,且观察组优于对照组。治疗前,两组CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)基本一致(P> 0.05);治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)高于治疗前,且观察组高于对照组,两组CD8^(+)基本一致(P> 0.05)。在复发率比较上,观察组低于对照组(P <0.05)。结论:应用糠酸莫米松鼻喷雾剂联合通窍鼻炎片治疗变应性鼻炎可减轻炎症反应,促进免疫功能的提升,显著降低复发率。

Objective: To explore the clinical efficacy of mometasone furoate nasal spray with the Tongqiao(通窍) rhinitis tablets on allergic rhinitis. Methods: 73 patients were divided into the control group(36 cases) and observation group(37 cases). The control group received only mometasone furoate nasal spray, and the observation group received the Tongqiao rhinitis tablets more. Results: IL-4 and IL-8 in the two groups were lower than before treatment, and those in the observation group was better than the control group. IFN-γ was higher than before treatment, and that in the observation group was higher than the control group. CD4^(+), CD4^(+)/CD8^(+) were higher than before treatment, and those in the observation group were higher than the control group, and CD8^(+) in the two groups was basically in accordance(P>0.05). The recurrence rate in the observation group was lower than the control group(P<0.05). Conclusion: Mometasone furoate nasal spray with the Tongqiao rhinitis tablets was effective, can reduce the inflammatory response, promote the improvement of immune function,and significantly reduce the recurrence rate.