内蒙古包头地区神经内分泌肿瘤回顾性分析

Retrospective analysis of neuroendocrine tumors in Baotou inner mongolia

目的分析内蒙古包头地区神经内分泌肿瘤(NEN)在发病年龄、部位、首发症状及可选择治疗方法方面存在的地区差异性。方法收集包头医学院第二附属医院消化科自2015年1月至2019年12月期间收治的胃肠NEN患者119例临床及病理资料,通过回顾性分析其发病性别、部位、症状和治疗措施,为胃肠NEN的临床治疗提供参考。结果通过本次研究共计119例患者,回顾性分析发病部位、症状和治疗措施所得到:(1)三组患者发病年龄不存在差异(P>0.05):G1组:年龄均值(50.89±11.073)岁;G2组:年龄均值(61.00±12.288)岁;G3组:年龄均值(66.38±12.07)岁;(2)食管、胃及结肠,患病发病率存在明显差异有统计学意义(χ^(2)=26.864,P<0.01);(3)食管、胃及结肠其首发症状不同:食管G3期患者明显均存在异物感。胃G2期患者首发症状存在反酸与烧心症状。与G1、G2期患者相比,结肠G3期患者明显存在腹痛症状。差别存在显著差异有统计学意义(P<0.05);(4)手术治疗8例(7.56%),全部为G3型患者、内镜黏膜下剥离术(ESD)治疗111例(92.44%)。结论胃肠道NEN因其发病部位不同及分级不同,则患者相关症状及治疗手段不同。

Objective To analyze the differences in age,site,first symptoms and treatment options of neuroendocrine tumors(NEN)in Baotou area.Methods The clinical and pathological data of 119 patients with gastrointestinal neuroendocrine tumors admitted from 2015 to 2019 in our hospital were collected.Through retrospective analysis of the onset sex,location,symptoms and treatment measures,we provided clinical treatment for gastrointestinal neuroendocrine tumor reference.Results Through this study,119 patients were retrospectively analyzed the site of the disease,symptoms and treatment measures:(1)According to different grades of value-added activity,there are not differences in age at onset,G1 stage average age is 50.89±11.073,G2 stage average age is 61.00±12.288,G3 stage average age is 66.38±12.070;(2)The histology of esophagus,stomach and colon was different,and the incidence of the disease was significantly different(χ^(2)=26.864,P=0,P<0.001),which was statistically significant.(3)The clinical manifestations of esophagus,stomach and colon are different due to their different diseased parts and stages.Patients with G3 stage have a foreign body sensation.Gastric G2 patients obviously have acid reflux and heartburn symptoms.Compared with patients with G1 and G2 phases,patients with colon G3 obviously have abdominal pain symptoms.There are significant differences(P<0.05);(4)8 patients(7.56%)were selected for surgical treatment,all of them were G3 patients;111 cases(92.44%)were treated with endoscopic mucosal dissection.Conclusion Due to the different sites and grades of GASTROINTESTINAL NEN,the related symptoms and treatment methods of patients are different.