组蛋白分子伴侣CAF-1与DNA损伤修复相关研究进展

Research Progress of Histone Chaperone CAF-1 and DNA Damage Repair

DNA的完整稳定是真核生物正常生命活动的基础,为了保证自身基因结构的稳定,生物体进化出了完整的DNA损伤反应(DDR)系统及应对各种损伤的修复系统。染色质作为生物遗传信息的承载,它的动态调节对包含DAN复制、转录、重组和修复等生物学过程在内的生命活动至关重要。组蛋白分子伴侣以不依赖ATP的方式在染色质组织中发挥着关键作用,影响着染色质的动力学变化。有研究表明,H3-H4组蛋白分子伴侣CAF-1在染色质相关的DNA损伤修复中发挥着一定作用。就近年来对CAF-1、DNA损伤修复及两者相关性的研究进行探讨,并对DNA损伤修复的深入研究进行展望。

The integrity and stability of DNA is the basis of normal life activities of eukaryotes.In order to ensure the stability of their own gene structure,organisms have evolved a complete DNA damage response(DDR)system and repair system to deal with various kinds of damage.Chromatin serves as the carrier of biological genetic information,and its dynamic regulation is essential for life activities including biological processes such as DAN replication,transcription,recombination and repair.Histone chaperones play a key role in chromatin tissue in an ATP-independent manner,affecting chromatin dynamics.The studies have shown that the H3-H4 histone chaperone CAF-1 plays a role in chromatin related DNA damage repair.In this paper,the research on CAF-1,DNA damage repair and the correlation between the two in recent years was discussed,and the further research on DNA damage repair was prospected.