维吾尔族终末期肾病患者脑局部一致性及功能连接改变

Changes of local brain coherence and functional connectivity of Uighur patients with end-stage renal disease

目的基于脑区局部一致性(ReHo)及种子点功能连接(FC)方法观察维吾尔族终末期肾病(ESRD)脑局部一致性及FC变化。方法对26例维吾尔族ESRD患者(试验组)及21名维吾尔族健康志愿者(对照组)采集静息态血氧水平依赖功能MRI(BOLD-fMRI),对比2组ReHo和全脑FC,获得组间ReHo和FC差异有统计学意义脑区的图像。结果最终试验组和对照组分别纳入23例ESRD及20名志愿者。相比对照组,试验组右侧小脑CrusⅡ及左侧楔前叶ReHo下降。基于右侧小脑CrusⅡ为种子点FC显示,试验组右侧小脑CrusⅡ种子点与左颞中回和右颞上回的FC下降;基于左侧楔前叶为种子点FC显示,试验组左侧楔前叶种子点与右侧楔前叶、左中扣带回的FC低于对照组。结论维吾尔族ESRD患者较健康维吾尔族成人右侧小脑CrusⅡ和左侧楔前叶ReHo及其与颞中回、颞上回、右侧楔前叶、中扣带回和后扣带回的FC下降。

Objective To observe the changes of local brain coherence and functional connectivity(FC)of Uyghur patients with end-stage renal disease(ESRD)based on regional homogeneity(ReHo)and seed-based FC methods with blood oxygen level-dependent functional MRI(BOLD-fMRI).Methods Data of BOLD-fMRI of 26 Uyghur ESRD patients(study group)and 21 healthy Uyghur volunteers(control group)were collected.ReHo and whole brain FC were analyzed,and brain regions with ReHo and FC being significantly different between groups were obtained.Results Totally 23 ESRD patients were enrolled in study group,while 20 healthy volunteers were included in control group after excluding participants with exceeded head motion.Compared with control group,ReHo significantly decreased in the right cerebellar CrusⅡand the left precuneus of study group.Taken FC of the right cerebellar CrusⅡas the seed point,FC between the seed point of the right cerebellar CrusⅡand the left middle temporal gyrus and the right superior temporal gyrus significantly decreased in study group compared with those in control group.Taken FC of the left precuneus as the seed point,FC between the left precuneus and the right precuneus,left middle cingulate gyrus in study group were significantly lower than that in control group.Conclusion Uyghur ESRD patients had lower ReHo in right cerebellar CrusⅡand left precuneus and lower FC between the above regions and middle temporal gyrus,superior temporal gyrus,right precuneus,middle and posterior cingulate than healthy Uyghur adults.