改良八式坐式太极拳对化疗期间肺癌患者健康相关生活质量的研究

Effect of modified eight-style sitting Tai Chi on health-related quality of life in lung cancer patients during chemotherapy

目的:观察改良八式坐式太极拳对化疗期间肺癌患者健康相关生活质量的影响。方法:59例患者分成干预组29例和对照组30例,对照组患者接受化疗科常规治疗,干预组在常规治疗的基础上,由康复治疗师指导,增加八式坐式太极拳训练,化疗期间每日一次,每次20~30min。分别于治疗前、治疗6周和12周末采用欧洲癌症研究治疗组织生活质量核心量表和肺癌特异性模块(EORTC QLQ-C30/LC13)对2组患者进行评估。结果:治疗6周后,干预组整体健康水平、角色功能、情绪功能、认知功能评分较治疗前均明显升高(均P<0.05),疲劳、恶心呕吐、呼吸困难、气促、手脚发麻及胸痛症状评分较治疗前均明显降低(均P<0.05);治疗12周后,干预组整体健康水平、躯体功能、角色功能、情绪功能、认知功能评分较治疗前均明显升高(均P<0.05),疲劳、恶心呕吐、呼吸困难、气促、咳嗽、手脚发麻及胸痛症状评分较治疗前均明显降低(均P<0.05);治疗6周后,对照组气促评分较治疗前明显降低(P<0.05);治疗12周后,对照组认知功能评分较治疗前明显升高(P<0.05),气促、手脚发麻及胸痛症状评分较治疗前均明显降低(均P<0.05);治疗6周后,2组差值比较,干预组整体健康水平、角色功能评分较对照组均明显提高(均P<0.05),疲劳、呼吸困难评分较对照组均明显降低(均P<0.05);治疗12周后,2组差值比较,干预组疲劳、呼吸困难得分较对照组均明显降低(均P<0.05)。结论:化疗期间监督下的改良八式坐式太极练习对肺癌患者来说是安全有益的,有助于改善肺癌患者健康相关生活质量。但本研究随访期较短,未来仍需对长期的功能指标进行深入的临床研究。

Objective:To observe the effect of modified eight-style sitting Tai Chi on the health-related quality of life in patients with lung cancer during chemotherapy.Methods:Totally,59 patients were divided into treatment group(29 cases)and control group(30 cases)in a prospective controlled trial.The control group received routine treatment in chemotherapy department,and the treatment group received eight-style sitting Tai Chi training once a day,20-30 min,guided by the therapist on basis of routine treatment.Before,and 6 weeks and 12 weeks after treatment,the patients in the two groups were evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30/lung cancer 13(EORTC QLQ-C30/LC13).Results:After 6 weeks of treatment,the scores of overall health level,role function,emotional function and cognitive function in the treatment group were significantly higher than those before treatment(all P<0.05),while the scores of fatigue,nausea and vomiting,dyspnea,dyspnea(LC13),numbness of hands and feet and pain in chest were significantly lower than those before treatment(all P<0.05).After 12 weeks of treatment,the scores of overall health,physical function,role function,emotional function and cognitive function in the treatment group were significantly higher than those before treatment(all P<0.05),while the scores of fatigue,nausea and vomiting,dyspnea,dyspnea(LC13),cough,numbness of hands and feet and pain in chest were significantly lower than those before treatment(all P<0.05).After 6 weeks of treatment,the dyspnea(LC13)score in the control group was significantly lower than that before treatment(P<0.05).After 12 weeks of treatment,the scores of cognitive function in the control group were significantly higher than those before treatment(P<0.05),while the scores of dyspnea(LC13),numbness of hands and feet and pain in chest were significantly lower than those before treatment(all P<0.05).After 6 weeks of treatment,the overall health level and role function scores in the treatment group were significantly higher than those in the control group(all P<0.05),while the scores of fatigue and dyspnea were significantly lower than those in the control group(all P<0.05).After 12 weeks of treatment,the scores of fatigue and dyspnea in the treatment group were significantly lower than those in the control group(all P<0.05).Conclusion:The modified eight-style sitting Tai Chi training under supervision during chemotherapy is safe and beneficial for patients with lung cancer.It can help improve health-related quality of life in lung cancer patients during chemotherapy.However,the follow-up period of this study is short,and in-depth clinical studies on long-term functional indicators need to be conducted in the future.