微波联合中耳注射甲强龙治疗急性分泌性中耳炎的疗效分析

Efficacy analysis of microwave combined with intratympanic injection of Sou-Medrol in the treatment of acute secretory otitis media

目的分析微波联合中耳注射甲泼尼龙琥珀酸钠(商品名:甲强龙)对急性分泌性中耳炎(ASOM)的临床治疗效果。方法174例(212耳)ASOM患者,随机分为对照组(56例,70耳)、实验组一(57例,70耳)及实验组二(61例,72耳)。对照组给予鼓膜穿刺治疗,实验组一在对照组基础上给予甲强龙注射治疗,实验组二在实验组一基础上给予微波治疗。比较三组的疗效、不良反应发生情况、鼓室积液完全消退时间及随访期间的复发率。结果实验组一、实验组二总有效率分别为84.3%、94.4%,均高于对照组的70.0%,差异有统计学意义(P<0.05);实验组二总有效率高于实验组一,差异有统计学意义(P<0.05)。治疗中三组均未发生严重不良反应。实验组一、实验组二的鼓室积液完全消退时间分别为(9.08±1.36)、(6.97±1.67)d,均短于对照组的(10.09±1.70)d,差异有统计学意义(P<0.05);实验组二鼓室积液完全消退时间短于实验组一,差异有统计学意义(P<0.05)。三组随访期间的复发率比较,差异无统计学意义(P>0.05)。结论鼓室内注射甲强龙治疗ASOM是安全的治疗方法,联合微波治疗,可显著提高临床疗效,值得在临床中推广。

Objective To analyze the clinical effect of microwave combined with methylprednisolone sodium succinate for injection(trade name:Sou-Medrol)in the treatment of acute secretory otitis media(ASOM).Methods A total of 174 patients(212 involved ears)with ASOM were randomly divided into control group(56 cases,70 involved ears),experimental group 1(57 cases,70 involved ears)and experimental group 2(61 cases,72 involved ears).The control group was treated with tympanum puncture,the experimental group 1 was treated with Sou-Medrol injectoin based on the control group,and the experimental group 2 was treated with microwave therapy based on the experimental group 2.The clinical efficacy,occurrence of adverse reactions,time to complete remission of tympanic effusion,and recurrence rate during follow-up were compared among the three groups.Results The total effective rates of the experimental group 1 and experimental group 2 were 84.3%and 94.4%,respectively,which were higher than 70.0%of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the experimental group 2 was higher than that of the experimental group 1,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in the three groups during treatment.The time to complete remission of tympanic effusion of the experimental group 1 and experimental group 2 were(9.08±1.36)and(6.97±1.67)d,respectively,which were shorter than(10.09±1.70)d of the control group,and the difference was statistically significant(P<0.05).The time to complete remission of tympanic effusion of the experimental group 2 was shorter than that of experimental group 1,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the recurrence rate among the three groups during follow-up(P>0.05).Conclusion Intratympanic injection of Sou-Medrol is a safe method in the treatment of ASOM.Combined with microwave therapy,it can significantly improve the clinical efficacy,which is worthy of clinical popularization.