慢性心衰经阿托伐他汀治疗的效果评估

Evaluation of the effect of atorvastatin on chronic heart failure

目的探讨慢性心力衰竭(心衰)经阿托伐他汀治疗的效果。方法94例慢性心衰患者,按照住院序号奇偶性分为对照组和观察组,各47例。对照组采用常规治疗,观察组采用阿托法他汀治疗。比较两组患者临床疗效以及治疗前后的心功能指标、血脂指标。结果观察组治疗总有效率95.74%高于对照组的82.98%,差异具有统计学意义(P<0.05)。治疗后,观察组患者左室射血分数(LVEF)(40.26±5.38)%、左室收缩末期容积指数(LVESVI)(46.25±7.69)ml/m^(2)、左室舒张末期容积指数(LVEDVI)(30.23±4.69)ml/m^(2),均优于对照组的(35.11±5.18)%、(52.87±7.73)ml/m^(2)、(34.74±4.97)ml/m^(2),差异均具有统计学意义(t=4.727、4.162、4.525,P=0.000、0.000、0.000<0.05)。治疗后,观察组患者总胆固醇(TC)(4.19±0.68)mmol/L、甘油三酯(TG)(1.84±0.35)mmol/L、低密度脂蛋白胆固醇(LDL-C)(2.54±0.61)mmol/L、高密度脂蛋白胆固醇(HDL-C)(1.18±0.17)mmol/L,均优于对照组的(5.40±1.02)、(2.57±0.31)、(4.07±0.83)、(1.03±0.15)mmol/L,差异均具有统计学意义(t=6.767、10.704、10.183、4.536,P=0.000、0.000、0.000、0.000<0.05)。结论采用阿托伐他汀治疗慢性心衰,可明显改善患者临床症状,促进心功能恢复正常。

Objective To discuss the effect of atorvastatin on chronic heart failure.Methods A total of 94 patients with chronic heart failure were divided into a control group and an observation group according to the parity of hospitalization serial numbers,with 47 cases in each group.The clinical efficacy,cardiac function indicators and blood lipid indicators before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 95.74%,which was higher than 82.98%of the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)(40.26±5.38)%,left ventricular end-systolic volume index(LVESVI)(46.25±7.69)ml/m^(2),and left ventricular end-diastolic volume index(LVEDVI)(30.23±4.69)ml/m^(2) of the observation group were better than(35.11±5.18)%,(52.87±7.73)ml/m^(2),(34.74±4.97)ml/m^(2) of the control group,and the difference was statistically significant(t=4.727,4.162,4.525;P=0.000,0.000,0.000<0.05).After treatment,the total cholesterol(TC)(4.19±0.68)mmol/L,triglycerides(TG)(1.84±0.35)mmol/L,low-density lipoprotein cholesterol(LDL-C)(2.54±0.61)mmol/L,and high-density lipoprotein cholesterol(HDL-C)(1.18±0.17)mmol/L of the observation group were superior to(5.40±1.02),(2.57±0.31),(4.07±0.83),and(1.03±0.15)mmol/L of the control group,all the differences was statistically significant(t=6.767,10.704,10.183,4.536;P=0.000,0.000,0.000,0.000<0.05).Conclusion Treatment of chronic heart failure with atorvastatin significantly can improve patients’clinical symptoms and promote normalization of cardiac function.