LISA技术在新生儿呼吸窘迫综合征中的应用效果

Application effect of LISA technology in neonatal respiratory distress syndrome

目的探究经胃微创注入肺表面活性物质(LISA)技术在新生儿呼吸窘迫综合征中的应用效果,分析LISA技术的优势。方法60例新生儿呼吸窘迫综合征患儿,采用随机分组法分为观察组及对照组,各30例。观察组给予LISA技术治疗,对照组给予传统的经气管插管注入肺表面活性物质(INSURE)技术治疗。比较两组血气分析指标、住院时间和氧疗时间。结果治疗后,观察组二氧化碳分压(32.02±1.55)mm Hg(1 mm Hg=0.133 kPa)低于对照组的(40.52±1.65)mm Hg,氧分压(97.52±1.52)mm Hg、血氧饱和度(97.60±1.51)%高于对照组的(79.05±1.52)mm Hg、血氧饱和度(88.52±1.54)%,差异有统计学意义(P<0.05)。观察组住院时间、氧疗时间均短于对照组,差异有统计学意义(P<0.05)。结论LISA技术在新生儿呼吸窘迫综合征中效果显著,能够显著改善患儿血气分析指标,同时能够缩短患儿住院时间和氧疗时间,促进患儿早期恢复健康,值得进一步研究。

Objective To investigate the application effect of less invasive surfactant administration(LISA)technology in neonatal respiratory distress syndrome.Methods A total of 60 infants with neonatal respiratory distress syndrome were randomly divided into observation group and control group,with 30 cases in each group.The observation group was treated with LISA technology,and the control group was treated with traditional intubation-surfactant-extubation(INSURE)technology via tracheal intubation.The blood gas analysis indexes,hospitalization time and oxygen therapy time were compared between the two groups.Results After treatment,the partial pressure of carbon dioxide(32.02±1.55)mm Hg(1 mm Hg=0.133 kPa)of the observation group was lower than(40.52±1.65)mm Hg of the control group,and the partial pressure of oxygen(97.52±1.52)mm Hg and blood oxygen saturation(97.60±1.51)%were higher than(79.05±1.52)mm Hg and(88.52±1.54)%of the control group.All the difference was statistically significant(P<0.05).The hospitalization time and oxygen therapy time of the observation group were shorter than those of the control group,and the difference was statistically significant(P<0.05).Conclusion The LISA technique is effective in neonatal respiratory distress syndrome.It can significantly improve the blood gas analysis indexes of the children.At the same time,it can shorten the hospitalization time and oxygen therapy time of the children,and promote the early recovery of the children.It is worthy of further study.