2型糖尿病应用胰岛素注射液联合利拉鲁肽治疗效果与血糖水平情况分析

Analysis of the Therapeutic Effect of Insulin Injection Combined with Liraglutide and Blood Glucose Level in Type 2 Diabetes

目的观察2型糖尿病应用胰岛素注射液联合利拉鲁肽治疗效果与血糖水平情况分析。方法将该院2019年1月—2021年1月收治的2型糖尿病患者142例以随机数表法分组,每组71例,其中接受2型糖尿病应用胰岛素注射液治疗为对照组,在对照组基础上联合利拉鲁肽治疗为研究组。比较两组患者治疗前后的血糖水平、胰岛功能指标、生活质量,判定临床治疗效果及不良反应。结果两组治疗前空腹血糖、餐后2 h水平相比,差异无统计学意义(P>0.05)。两组治疗后空腹血糖、餐后2 h水平均较治疗前明显降低,研究组与对照组相比则更低,差异有统计学意义(P<0.05)。两组治疗前胰岛功能指标水平相比,差异无统计学意义(P>0.05)。两组治疗后胰岛功能指标水平较治疗前改善,HomaIR指标研究组较对照组更低,HomaB指标较对照组更高,差异有统计学意义(P<0.05)。研究组患者治疗后总有效率与对照组相比更高,差异有统计学意义(P<0.05)。研究组患者治疗过程中不良反应率较对照组更低,差异有统计学意义(P<0.05)。两组治疗前生活质量评分相比,差异无统计学意义(P>0.05)。两组治疗后生活质量较治疗前提升,研究组较对照组更高,差异有统计学意义(P<0.05)。结论在2型糖尿病患者在治疗方法的选择中,以胰岛素注射液联合利拉鲁肽治疗,可以明显改善胰岛功能指标,降低且平稳患者的血糖指标,获得更高的治疗有效率,减少治疗过程中的不良反应,改善患者的生活质量,效果理想。

Objective To observe the therapeutic effect of insulin injection combined with liraglutide and analyze the blood glucose level of type 2 diabetes.Methods 142 patients with type 2 diabetes were admitted to the hospital from January 2019 to January 2021.Patients with type 2 diabetes were divided into groups of 71 patients in each group by a random number table,of which were treated with insulin injection for type 2 diabetes as the control group,the other were treated with liraglutide on the basis of the control group as the study group.The blood glucose levels,islet function indexes,and quality of life of the two groups of patients before and after treatment were compared to determine the clinical treatment effects and adverse reactions.Results The difference between the two groups of fasting blood glucose before treatment and the level of 2 h after meal was not statistically significant(P>0.05).The fasting blood glucose and 2 h levels after the meal were significantly lower in the two groups after treatment than before the treatment,and the study group was lower than the control group,and the difference was statistically significant(P<0.05).The difference between the two groups of islet function index levels before treatment was not statistically significant(P>0.05).The levels of islet function indexes in the two groups improved after treatment.The HomaIR index in the study group was lower than the control group,and the HomaB index was higher than the control group.The difference was statistically significant(P<0.05).The total effective rate after treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The adverse reaction rate of patients in the study group was lower than that in the control group during treatment,and the difference was statistically significant(P<0.05).Compared with the quality of life scores before treatment,the difference between the two groups was not statistically significant(P>0.05).The quality of life of the two groups after treatment was improved compared with that before treatment,and the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the selection of treatment methods for patients with type 2 diabetes,the combination of insulin injection and laglutide can significantly improve the islet function,reduce and stabilize the blood glucose of patients,and obtain higher treatment efficiency,reduce adverse reactions in the treatment process,improve the quality of life of patients,and the effect is ideal.