动态血糖监测在糖尿病肾病中的临床应用价值研究

Study on the Clinical Application Value of Dynamic Blood Glucose Monitoring in Diabetic Nephropathy

目的探讨动态血糖监测在糖尿病肾病中的临床应用价值。方法选取该院2019年6月—2020年4月收治的糖尿病肾病患者60例,以随机数字表法将患者分为两组。对照组30例指导进行自我血糖监测,研究组30例给予动态血糖监测,连续进行14 d血糖监测后,对比两组患者日均高血糖持续时间、日均血糖波动范围、空腹血糖(FPG)、餐后2 h血糖(2 hPG)水平、糖化血红蛋白(HbAlc)水平、24 h尿蛋白定量、血肌酐(SCr)、TIR指标、自我管理水平(SDSCA-6)评分。结果研究组日均高血糖持续时间明显短于对照组,差异有统计学意义(P<0.05);研究组日均血糖波动范围明显小于对照组,差异有统计学意义(P<0.05);两组接受血糖监测前,FPG水平、2 hPG水平、HbAlc水平、24 h尿蛋白定量、SCr水平、TIR指标、SDSCA-6评分比较,差异无统计学意义(P>0.05)。接受血糖监测后,研究组FPG水平、2 hPG水平、HbAlc水平、24 h尿蛋白定量、SCr水平、TIR指标低于对照组,SDSCA-6评分高于对照组,差异有统计学意义(P<0.05)。结论动态血糖监测应用于糖尿病肾病患者中,有利于控制患者血糖波动,缩短高血糖持续时间,促进血糖平衡,减少肾功能损伤,提高糖尿病患者自我管理能力,具有较高临床应用价值。

Objective To explore the clinical application value of dynamic blood glucose monitoring in diabetic nephropathy.Methods A total of 60 patients with diabetic nephropathy admitted to the hospital from June 2019 to April 2020 were selected.The patients were divided into two groups by a random number table.30 patients in the control group were guided by self-monitoring of blood glucose,and 30 patients in the study group were given dynamic blood glucose monitoring,after 14 days of continuous blood glucose monitoring,the two groups of patients were compared with the average daily duration of hyperglycemia,daily average blood glucose fluctuation range,fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2 hPG)level,glycosylated hemoglobin(HbAlc)level,and 24 h urine protein quantification,blood creatinine(SCr),TIR index,self-management level(SDSCA-6)score.Results The duration of average daily hyperglycemia in the study group was significantly shorter than that in the control group,and the difference in data was statistically significant(P<0.05);the fluctuation range of daily average blood glucose in the study group was significantly smaller than that in the control group,and the difference in data was statistically significant(P<0.05);before the group received blood glucose monitoring,the difference of FPG level,2 hPG level,HbAlc level,24 h urine protein quantification,SCr level,TIR index,SDSCA-6 score was not statistically significant(P>0.05).After receiving blood glucose monitoring,the study group's FPG level,2 hPG level,HbAlc level,24 h urine protein quantification,SCr level,and TIR indicators were lower than those of the control group,and the SDSCA-6 score was higher than that of the control group.The data difference was statistically significant(P<0.05).Conclusion The application of dynamic blood glucose monitoring in patients with diabetic nephropathy is beneficial to control blood glucose fluctuations,shorten the duration of hyperglycemia,promote blood glucose balance,reduce renal function damage,and improve the self-management ability of diabetic patients.It has high clinical application value.