谷胱甘肽和血清五聚素3对冠心病患者冠状动脉狭窄程度的评估价值

The Evaluation Value of Glutathione and Pentapeptidase 3 on the Degree of Coronary Artery Stenosis in Patients with Coronary Heart Disease

目的:探讨生物标志物对评价冠心病患者冠状动脉狭窄程度的潜在价值。方法:通过冠状动脉造影定量测量Gensini评分(GS)评价冠状动脉粥样硬化程度。对156例患者按GS分为低GS组(n=48)、中GS组(n=56)和高GS组(n=52),测定血脑钠素、谷胱甘肽(CPP)、磷酸二酯酶9A(PDE9A)和血清五聚素3(PTX3)水平。结果:高GS组CPP和PTX3水平明显高于低GS组。此外,Pearson相关分析表明,CPP和PTX3与GS呈正相关。CPP和PTX3对评价冠状动脉狭窄程度均有一定的区分能力。结论:无创性实验室检测CPP和PTX3可为冠心病患者有创血管造影前的危险分层和疾病管理提供新的信息。

OBJECTIVE To explore the potential value of biomarkers in evaluating the degree of coronary artery stenosis in pa-tients with coronary heart disease.METHODS The Gensini score(GS)was quantitatively measured by coronary angiography to eval-uate the degree of coronary atherosclerosis.According to the GS classification,156 patients were divided into low GS group(n=48),medium GS group(n=56)and high GS group(n=52).Blood brain natriuretic peptide,glutathione(CPP),phosphodiester-ase 9 A(PDE9 A)and pentapeptidase 3(PTX3)levels.RESULTS The plasma CPP and PTX3 levels in the high GS group were sig-nificantly higher than those in the low GS group.In addition,pearson correlation analysis showed that CPP and PTX3 were positivelycorrelated with GS,CPP and PTX3.CPP and PTX3 had a certain ability to distinguish the degree of coronary artery stenosis.CONCLUSION Non-invasive laboratory testing of CPP and PTX3 could provide new information for risk stratification and disease manage-ment in patients with coronary heart disease before invasive angiography.