甘精胰岛素联合用药控制初发2型糖尿病血糖

Glycemic Control of Newly Diagnosed Type 2 Diabetes Mellitus With Insulin Glargine

目的观察不同药物方案对初发2型糖尿病(T2DM)患者血糖波动的影响。方法选择2019年1月—2020年2月收治的90例初发T2DM患者,随机分为Ⅰ、Ⅱ组,均给予甘精胰岛素治疗,在此基础上分别联合沙格列汀、阿卡波糖,比较两组临床疗效。结果治疗后,治疗后,两组患者BMI、FBG、2 hPG、HbA1c水平均低于治疗前,差异有统计学意义(P<0.05),和Ⅰ组相比较,Ⅱ组患者HbA1c、MAGE、MODD、高血糖AUC及NGE均低于Ⅰ组,差异有统计学意义(P<0.05);低血糖AUC水平差异无统计学意义(P>0.05);解读72 h动态血糖监测结果,治疗后各组均有2例患者发生低血糖。结论阿卡波糖联合甘精胰岛素治疗初发T2DM,能更有效的改善血糖波动状态,降低HbA1c水平,稳定性较好。

Objective To observe the effect of different drug regimens on blood glucose fluctuation in newly diagnosed type 2 diabetes mellitus(T2DM).Methods 90 patients with newly diagnosed T2DM from January 2019 to February 2020 were selected and randomly divided into groupⅠand groupⅡ,which were treated with insulin glargine.On this basis,the clinical effects of two groups were compared.Results After treatment,the levels of BMI,FBG,2 hPG and HbA1c in 2 groups were lower than before,the differences were statistically significant(P<0.05).Compared with groupⅠ,HbA1c,MAGE,MODD,hyperglycemia AUC and NGE in groupⅡwere lower than groupⅠ,the differences were statistically significant(P<0.05).There was no significant difference in AUC level in hypoglycemia(P>0.05).Interpreting the results of 72 h dynamic blood glucose monitoring,2 patients in each group developed hypoglycemia after treatment.Conclusion Acarbose combined with insulin glargine in the treatment of newly diagnosed T2DM can effectively improve the fluctuation of blood glucose and reduce the level of HbA1c,which is stable and worthy of promotion.