高压氧不同时机应用对重度颅脑外伤患者的临床疗效比较

Comparison of the Clinical Effects of Hyperbaric Oxygen at Different Times on Patients with Severe Head Injury

目的探讨高压氧不同时机应用对重度颅脑外伤患者的临床效果。方法选择2018年1月—2019年12月,该院收治的重度颅脑外伤患者,根据抽签法抽取86例进行研究,按照患者先后入院时间分为对照组、研究组,每组43例,对照组于伤后16~30 d内进行高压氧治疗,研究组于伤后8~12 d内进行高压氧治疗,比较两组治疗效果、苏醒时间、住院时间,治疗前后残疾程度(DRS)、颅脑损伤程度(GOS)。结果与对照组治疗总有效率(81.40%)进行比较,研究组(97.67%)显著较高,差异有统计学意义(χ^(2)=4.467,P=0.034);治疗前,两组DRS、GOS评分差异无统计学意义(t=0.341、1.125,P>0.05);治疗后,比较对照组DRS(17.04±2.07)分、GOS(3.78±0.92)分,研究组分别为(15.20±1.64)分、(4.68±0.34)分;对比对照组苏醒时间(23.54±4.40)d、住院时间(69.25±5.17)d,研究组分别为(18.60±3.12)、(51.65±3.24)d,数据差异有统计学意义(t=4.569、6.017、6.006、18.916,P<0.05)。结论对于重度颅脑损伤患者,于早期(伤后8~12 d)进行高压氧治疗可显著提高患者治疗总有效率,改善残疾程度、颅脑损伤程度,价值显著,值得推广。

Objective To investigate the clinical effects of hyperbaric oxygen at different times on patients with severe traumatic brain injury.Methods Selected January 2018 to December 2019,the patients with severe head injury collected in the hospital.According to the lottery method,86 cases were selected for research.The patients were divided into a control group and a study group according to the time they were admitted to the hospital.Each group of 43 cases,the control group received hyperbaric oxygen therapy within 16-30 d after injury,and the study group received hyperbaric oxygen therapy within 8-12 d after injury.The treatment effects,recovery time,hospital stay,and degree of disability before and after treatment(DRS),the degree of head injury(GOS),of the two groups were compared.Results Compared with the total effective rate of treatment in the control group(81.40%).The study group(97.67%)was significantly higher and the difference was statistically significant(χ^(2)=4.467,P=0.034);before treatment,there was no statistically difference in DRS and GOS scores between the two groups(t=0.341,1.125,P>0.05);after treatment,compared the DRS(17.04±2.07)points and GOS(3.78±0.92)points of the control group and(15.20±1.64)points,(4.68±0.34)points of the study group respectively;compared with the control group's wake-up time(23.54±4.40)d and hospitalization time(69.25±5.17)d,the study group was(18.60±3.12)d and(51.65±3.24)d,and there were statistically significant differences in data(t=4.569,6.017,6.006,18.916,P<0.05).Conclusion For patients with severe head injury,hyperbaric oxygen therapy at an early stage(8-12 days after injury)can significantly increase the total effective rate of treatment,improve the degree of disability and the degree of brain injury,and is of significant value and is worthy of promotion.