长期雾化吸入糖皮质激素对哮喘儿童内分泌功能的影响

Effect of Long-term Aerosol Inhalation of Corticosteroids on Endocrine Function in Children with Asthma

哮喘是影响儿童健康的常见慢性呼吸系统疾病,发病率呈逐年上升趋势。吸入糖皮质激素(inhaled glucocorticoids,ICS)在控制哮喘症状、改善肺功能、提高生活质量等方面疗效显著,得到了许多国际指南的广泛推荐。虽然ICS较口服糖皮质激素更为安全,但长期使用ICS是否对儿童内分泌功能产生的影响,目前尚无统一结论。这也影响着哮喘患儿治疗的依从性,进而影响哮喘的防控效果。该文拟从生长发育、肾上腺功能、骨质代谢、性腺、糖代谢等方面,综述ICS对哮喘儿童内分泌功能的影响。

Asthma is a common chronic respiratory disease that affects children's health,and the incidence is increasing year by year.Inhaled glucocorticoids(ICS)are effective in controlling asthma symptoms,improving lung function,and improving quality of life,and have been widely recommended by many international guidelines.Although ICS is safer than oral glucocorticoids,whether long-term use of ICS has an impact on children's endocrine function,there is currently no unified conclusion.This also affects the compliance of children with asthma,which in turn affects the effectiveness of asthma prevention and control.This article intends to review the effects of ICS on the endocrine function of children with asthma in terms of growth and development,adrenal gland function,bone metabolism,gonads,and glucose metabolism.