双歧杆菌四联活菌片治疗对胆囊切除术后腹泻患者胃肠激素水平的影响

Effect of Bifidobacterium Quadruple Live Bacteria Tablets on Gastrointestinal Hormone Levels in Patients with Diarrhea After Cholecystectomy

目的探讨胆囊切除术后腹泻患者实施双歧杆菌四联活菌片治疗对其胃肠激素水平的影响。方法选取2019年10月至2020年10月东港市中心医院收治的胆囊切除术后腹泻患者102例作为研究对象,随机分为对照组与试验组,各51例。采用常规治疗的胆囊切除术后腹泻患者作为对照组,在采用常规治疗基础上实施双歧杆菌四联活菌片治疗的胆囊切除术后腹泻患者作为试验组。比较两组胆囊切除术后腹泻患者经过不同治疗后的肠道菌群数量、胃肠激素水平、临床治疗效果以及腹泻复发率。结果治疗后,试验组大肠杆菌数量为(7.01±0.57)CFU/g、双歧杆菌数量为(9.22±0.85)CFU/g、乳酸杆菌数量为(8.80±0.79)CFU/g优于对照组,差异有统计学意义(P<0.05);试验组5-羟色胺水平为(48.09±7.80)ng/L、血管活性肠肽水平为(88.49±15.33)ng/L,明显低于对照组,差异有统计学意义(P<0.05)。试验组治疗有效率为94.12%,明显高于对照组,差异有统计学意义(P<0.05);试验组腹泻复发率为3.92%,明显低于对照组,差异有统计学意义(P<0.05)。结论胆囊切除术后腹泻患者使用双歧杆菌四联活菌片治疗的临床效果显著,能够调节患者胃肠激素水平,改善患者腹泻症状,促进患者恢复健康,减少腹泻复发。

Objective To explore the effect of Bifidobacterium quadruple live bacteria tablets on gastrointestinal hormone levels in patients with diarrhea after cholecystectomy. Methods A total of 102 patients with diarrhea after cholecystectomy admitted to Donggang Central Hospital from October 2019 to October 2020 were selected as the research objects, and were randomly divided into a control group and a test group, with 51 cases in each group. Patients with diarrhea after cholecystectomy with conventional treatment were used as the control group, and patients with diarrhea after cholecystectomy who were treated with bifidobacterium quadruple viable tablets on the basis of conventional treatment. The number of intestinal flora, gastrointestinal hormone levels, clinical treatment effect and recurrence rate of diarrhea after different treatments were compared between the 2 groups of patients with diarrhea after cholecystectomy. Results After the treatment, the number of escherichia coli in the test group was(7.01±0.57) CFU/g, the number of bifidobacteria was(9.22±0.85) CFU/g, and the number of lactobacilli was(8.80±0.79) CFU/g, better than the control group, the difference was statistically significant(P<0.05);the serotonin level of the test group was(48.09±7.80) ng/L, and the level of vasoactive intestinal peptide was(88.49±15.33) ng/L, which was significantly lower than that of the control group. The difference was statistically significant(P<0.05). The effective rate of treatment in the test group was 94.12%, which was significantly higher than that of the control group, and the difference was statistically significant(P<0.05);the recurrence rate of diarrhea in the test group was 3.92%, which was significantly lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Patients with diarrhea after cholecystectomy have a significant clinical effect of using bifidobacterium quadruple viable bacteria tablets, which can regulate the gastrointestinal hormone levels of the patients, improve the symptoms of diarrhea, promote the recovery of the patients, and reduce the recurrence of diarrhea.