线粒体动力学与心血管疾病联系的研究进展

Advances in research on the relationship between mitochondrial dynamics and cardiovascular disease

线粒体是高度动态的细胞器,为了维持其完整性、分布和大小而不断经历着生物发生、融合、裂变和降解的协调循环,这个过程称为线粒体动力学。越来越多的证据表明,在各种疾病模型中,线粒体动力学的损伤会导致心肌损伤并且加速心血管疾病的进展,包括压力超载、缺血/再灌注和代谢紊乱等。调控线粒体动力学可能被认为是一种有效的心血管疾病治疗策略。因此,该文综述了有关线粒体动力学和心血管疾病联系的最新研究进展,希望有助于根据线粒体动力学理论优化心血管疾病治疗策略。

Mitochondria are highly dynamic organelles that undergo coordinated cycles of biogenesis,fusion,fission,and degradation,called as mitochondrial dynamics,in order to maintain their integrity,distribution,and size.A great deal of evidence has suggested that in various disease models,mitochondrial dynamics damage can lead to myocardial injury and accelerate the progression of cardiovascular diseases,including pressure overload,ischemia reperfusion and metabolic disorders.Modulating mitochondrial dynamics may be considered as an effective strategy for the treatment of cardiovascular disease.Therefore,this paper reviewed the latest research status quo on the relationship between mitochondrial dynamics and cardiovascular diseases,and incorporated the theories of mitochondrial dynamics in an attempt to optimize the therapeutic strategies of cardiovascular diseases.