微小RNA与高血压关系研究进展

Research progress on the relationship between miRNA and hypertension

原发性高血压(essential hypertension, EH)是一个重要的公共卫生问题,是多种心血管疾病的危险因素。微小RNA (microRNA, miRNA)是一种非编码的小RNA,在转录后水平调控靶mRNA的表达。近年来大量研究表明,miRNA通过多种途径参与到高血压的发生发展中,包括引发血管内皮细胞功能障碍、血管平滑肌细胞的表型转化以及对肾素-血管紧张素系统的过激反应等。该文综述了近年来miRNA在高血压中的研究进展,以期阐明其在高血压发生发展中的作用机制,为探索高血压新的治疗靶点提供思路。

Essential hypertension is an important public health problem, and is a risk factor for many kinds of cardiovascular diseases. MicroRNAs(miRNAs) are small non-coding RNAs that regulate the expression of target mRNAs at the post-transcriptional level. In recent years, a large number of studies have shown that miRNAs are involved in the occurrence and development of hypertension through a variety of ways, including triggering vascular endothelial cell dysfunction, phenotype transformation of vascular smooth muscle cell, and overreaction to renin-angiotensin system, etc. In this article, the research progress of miRNA in hypertension in recent years is reviewed, with a view to elucidate its mechanism in the occurrence and development of hypertension and to provide ideas for exploring new therapeutic targets for hypertension.