血清MCP-1、CXCL8水平预测早期乳腺癌患者保乳术后复发转移的价值

Serum MCP-1 and CXCL8 levels predict the recurrence and metastasis of early breast cancer patients after breast conserving surgery

目的探讨血清单核细胞趋化因子-1(MCP-1)、趋化因子配体8(CXCL8)水平预测早期乳腺癌(EBC)患者保乳术后复发转移的价值。方法回顾性分析2016年1月至2017年12月在南阳市第一人民医院完成保乳手术治疗的138例EBC患者的临床资料,患者术后均完成随访3年。统计所有EBC患者术后复发转移发生情况,并收集其基线资料,分析血清MCP-1、CXCL8水平预测早期乳腺癌患者保乳术后复发转移的价值。结果纳入的138例EBC患者中12例术后发生复发转移,发生率为8.70%;发生复发转移组术前血清MCP-1、CXCL8水平均高于未发生复发转移组(P<0.05);组间其余资料比较,差异未见统计学意义(P>0.05);绘制受试者工作曲线(ROC),结果显示,术前血清MCP-1、CXCL8水平单独及联合预测EBC患者保乳术后复发转移发生风险的曲线下面积(AUC)均>0.80,预测价值均理想,且以联合预测价值最佳。结论术前血清MCP-1、CXCL8水平对EBC患者保乳术后复发转移的发生有一定预测价值,二者高表达可能提示复发转移风险较高。

Objective To investigate the value of serum monocyte chemoattractant factor-1(MCP-1)and chemokine ligand 8(CXCL8)levels in predicting the recurrence and metastasis of early breast cancer(EBC)patients after breast conserving surgery.Methods The clinical data of 138 patients with EBC who underwent breast conserving surgery in Nanyang First People’s Hospital from January 2016 to December 2017 were retrospectively analyzed.All patients were followed up for 3 years.The incidence of postoperative recurrence and metastasis in all patients with EBC was analyzed,and the baseline data and the serum MCP-1 and CXCL8 levels were collected.The value of serum MCP-1 and CXCL8 levels in predicting recurrence and metastasis of early breast cancer patients after breast conserving surgery was analyzed.Results In 138 patients with EBC,12 patients had postoperative recurrence and metastasis,the incidence rate was 8.70%;the preoperative serum MCP-1 and CXCL8 levels in the recurrence and metastasis group were higher than those in the non recurrence and metastasis group(P<0.05);there was no statistically significant difference in other data between the groups(P>0.05).The receiver operating curve(ROC)was drawn,the results showed that the area under curve(AUC)of preoperative serum MCP-1 and CXCL8 levels alone and combined to predict the risk of recurrence and metastasis of EBC patients after breast conserving surgery was>0.80,and the combined predictive value was the best.Conclusions Preoperative serum MCP-1 and CXCL8 levels can predict the recurrence and metastasis of EBC patients after breast conserving surgery.The high expression of MCP-1 and CXCL8 may indicate a higher risk of recurrence and metastasis.