康艾注射液联合含铂化疗药物治疗老年晚期非小细胞肺癌的临床研究

Kang Ai Injection Combined with Platinum-Containing Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in Older Patients

目的探究康艾注射液联合含铂化疗药物对老年晚期非小细胞肺癌的临床治疗效果。方法选取河北省邯郸市华北医疗峰峰总医院就诊的晚期非小细胞肺癌的老年患者90例,将其随机分为观察组与对照组,对照组患者采用含铂化疗药物治疗,观察组患者采用康艾注射液联合含铂化疗药物治疗,比较两组患者近期的临床疗效、生活质量和不良反应发生率,并对两组患者的1年生存率进行分析。结果观察组临床有效率、卡氏功能状态评分(KPS)改善率高于对照组,差异均有统计学意义(P<0.05);观察组的中位生存时间长于对照组,观察组的1年生存率高于对照组,差异均具有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论康艾注射液联合含铂化疗药物治疗老年晚期非小细胞肺癌可以提高患者的近期生存率及生存质量,且不增加不良反应发生率。

Objective To analyze the clinical efficacy of kang ai injection combined with platinum-containing chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC).Methods 90 older patients with advanced NSCLC were enrolled in North China Medical Fengfeng General Hospital.The patients were randomly divided into the observation group and the control group.The control group was treated with platinum-containing chemotherapy,while the observation group was additionally treated with kang ai injection.The clinical efficacy,quality of life and incidence of adverse reactions were compared between the two groups.The 1-year survival rate was analyzed.Results The response rate and KPS improvement rate in the observation group were higher than those in the control group(P<0.05).The median survival time was longer and 1-year survival rate was higher in the observation group than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Kang ai injection combined with platinum-containing chemotherapy may prolong the short-term survival,improve the quality of life,and does not increase the incidence of adverse reactions in older patients with advanced NSCLC.