摘要
白细胞介素18(IL-18)是IL-1家族具有诱导干扰素-γ(IFN-γ)功能的促炎细胞因子,具有增强自然杀伤(NK)细胞的细胞毒性、促进T细胞增殖的作用。IL-18与IL-12协同作用可促进Th1细胞分化,与IL-2结合可以刺激细胞毒性T细胞、NK细胞产生IFN-γ,发挥抑癌或致癌的双重作用。在癌症的治疗过程中,IL-18与免疫检查点抑制剂联合使用,能够有效抑制癌症的发展。本文对IL-18的生物学活性,在癌症发生、发展过程中的两面性及免疫治疗中的作用做一综述。
Interleukin-18(IL-18)is a proinflammatory cytokine of interleukin-1(IL-1)family with the function of inducing interferon-γ(IFN-γ),which enhances the cytotoxicity of natural killer(NK)cells and promotes the proliferation of T cells.The synergistic effect of IL-18 and IL-12 promotes the differentiation of Th1 cells,and the combination with interleukin-2(IL-2)can stimulate the production of IFN-γby cytotoxic T cells and NK cells,thus playing a dual role of tumor suppressor or carcinogenesis.In the treatment of cancer,IL-18 is used in combination with immune checkpoint inhibitors,which effectively inhibits the development of cancer.This article reviews the biological activity of IL-18,its dual role in the occurrence and development of cancer and its role in immunotherapy.
作者
郭磊
辛本凯
沈若琪
张纪周
肖业臣
Guo Lei;Xin Benkai;Shen Ruoqi;Zhang Jizhou;Xiao Yechen(Department of Biochemistry,College of Basic Medical Sciences,Jilin University,Changchun 130021;School of Public Health,Jilin University,Changchun 130021;Department of Biotechnology,College of Basic Medical Sciences,Guangdong Medical University,Dongguan 523000)
出处
《国际老年医学杂志》
2021年第5期305-308,共4页
International Journal of Geriatrics
基金
吉林省重点科技研发项目(20180201030YY)。
