中药复方治疗慢性阻塞性肺疾病合并焦虑抑郁的用药规律

Medication Rules of Chinese Herbal Compounds in the Treatment of Chronic Obstructive Pulmonary Disease Combined with Anxiety and Depression

目的:运用文献数据挖掘的方式,收集全网文献中有关治疗慢性阻塞性肺疾病(COPD)合并焦虑抑郁的中药复方,探讨其用药规律。方法:检索1990年1月1日至2020年3月1日中国知网、万方、重庆维普、中国生物医学文献数据库里收录的文献,将收集所得的处方运用频数分析、聚类分析、关联规则分析进行数据挖掘。结果:频数分析显示所得40首处方共涉及药物92味,使用频次≥5次的中药有25味,使用频次在前11位(使用频次≥10)的是甘草、柴胡、黄芪、茯苓、白术、陈皮、党参、枳壳、五味子、白芍、川芎;频次居前4位的药物类别分别是补虚药、化痰止咳平喘药、理气药、活血化瘀药;药性以寒、温、平为主;药味以甘为首;归经以肺经为要;对高频药物进行聚类分析后得到5个聚类新方;关联规则分析共提取20个常用药物组合。结论:COPD合并焦虑抑郁的中医药治疗以补气药为主,同时辅以理气、祛瘀、化痰药。

Objective:To collect Chinese herbal compounds in the treatment of chronic obstructive pulmonary disease(COPD)combined with anxiety and depression in the literature of the entire network by using literature data mining methods and to explore its medication rules.Methods:The documents included in the China National Knowledge Base,Wanfang,Chongqing VIP,and China Biomedical Literature Database from January 1st,1990 to March 1st,2020 were retrieved and the collected prescriptions were analyzed by frequency analysis,cluster analysis and association rules for data mining.Results:Frequency analysis showed that 40 prescriptions were collected.There were 92 Chinese medicinals involved.Among them,25 Chinese medicinals were used with frequency≥5 times,and the top 11 used frequency(use frequency≥10)were Gancao(Glycyrrhizae Radix et Rhizhoma),Chaihu(Bupleuri Radix),Huangqi(Astragali Radix),Fuling(Poria),Baizhu(Atractylodes),Chenpi(Citri Reticulatae Pericarpium),Dangshen(Codonopsis Radix),Zhiqiao(Aurantii Fructus),Wuweizi(Schisandrae Chinensis Fructus),Baishao(Paeoniae Radix alba)and Chuanxiong(Chuanxiong Rhizoma).The top 4 medicinal categories were tonics,medicinals for resolving phlegm and relieving cough and asthma,medicinals for regulating qi,and medicinals for activating blood and resolving stasis.The medicinal properties were mainly cold,warm and neutral.The top taste of medicine is sweet and the top meridian is the lung meridian.Five new clustering prescriptions were obtained after cluster analysis of high-frequency medicines.Total 20 commonly used herbal combinations were extracted by association rule analysis.Conclusion:COPD combined with anxiety and depression was mainly treated with medicinals for tonifying qi,supplemented by medicinals for regulating qi,resolving stasis and resolving phlegm.