新生儿B族链球菌感染的临床分析

Clinical Analysis of Neonatal Group B Streptococcal Infection

目的对新生儿B族链球菌感染情况进行分析,从而为制定降低新生儿B族链球菌感染的措施和治疗新生儿B族链球菌感染的方案提供指导。方法择取2016年2月-2019年2月该院产科接收的B族链球菌感染孕妇,予以产时抗生素预防治疗后分娩的新生儿265例,将其设定为研究组。同时纳入2013年1月-2016年1月该院B族链球菌临床标本培养为阳性的新生儿94例,将其设定为对照组。记录两组基本情况、B族链球菌感染发生情况、各位置B族链球菌阳性测定情况。结果对照组新生儿肺炎51.06%、败血症5.31%和脑膜炎4.25%发生率高于研究组5.28%、0.76%、0.38%,两组对比差异有统计学意义(χ^(2)=98.606、5.362、45.036,P<0.05);研究组与对照组呼吸道样本(0.38%vs 96.81%)、血液样本阳性检出率(0.76 vs 5.32%)对比差异有统计学意义(χ^(2)=338.535、5.362,P=0.001、0.020)。结论对于妊娠34~40周的孕妇应予以B族链球菌筛查,从而及时对B族链球菌感染孕妇干预,对于新生儿B族链球菌感染则立即予以治疗。

Objective To analyze the neonatal group B streptococcal infection,so as to provide guidance for formulating measures to reduce neonatal group B streptococcal infection and the treatment of neonatal group B streptococcal infection.Methods Selected pregnant women with group B streptococcus infection received from the obstetrics department of the hospital between February 2016 to February 2019,and 265 newborns who gave birth after receiving intrapartum antibiotic prophylaxis and set them as the study group.At the same time,94 neonates whose clinical specimens of group B streptococcus were cultured in the hospital from January 2013 to January 2016 were included,and they were set as the control group.The basic information of the two groups,the occurrence of group B streptococcus infection,and the positive determination of group B streptococcus in each location were recorded.Results The incidences of neonatal pneumonia 51.06%,sepsis 5.31%and meningitis 4.25%in the control group were higher than those in the study group 5.28%,0.76%,and 0.38%.The difference between the two groups was statistically significant(χ^(2)=98.606,5.362,45.036,P<0.05);compared with the study group and control group respiratory samples(0.38%vs 96.81%),blood samples positive detection rate(0.76 vs 5.32%),the difference was statistically significant(χ^(2)=338.535,5.362,P=0.001,0.020).Conclusion Pregnant women who are 34-40 weeks of gestation should be screened for group B streptococcus,so that pregnant women with group B streptococcus infection should be intervened in time,and for newborns with group B streptococcus infection,they should be treated immediately.