氯沙坦钾联合前列地尔治疗慢性肾小球肾炎的作用分析

Analysis of the Effect of Losartan Potassium Combined with Alprostadil in the Treatment of Chronic Glomerulonephritis

目的分析氯沙坦钾联合前列地尔治疗慢性肾小球肾炎的作用。方法选取2019年8月-2020年8月该院收治的93例慢性肾小球肾炎患者作为研究对象,随机数表法分两组。均给予两组常规治疗,在此基础上,给予对照组(46例)氯沙坦钾,给予观察组(47例)氯沙坦钾联合前列地尔,比较疗效、肾功能变化、不良反应。结果对照组总疗效为78.26%,观察组为93.62%,组间比较,观察组较高,差异有统计学意义(χ^(2)=4.559,P<0.05);两组3项肾功能指标[肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白定量]经治疗后均降低,差异有统计学意义(P<0.05),组间比较,观察组均较低,差异有统计学意义(P<0.05);对照组不良反应总发生率为10.87%,观察组为8.51%,组间比较,差异无统计学意义(χ^(2)=0.001,P>0.05);两组3项炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]治疗后水平均降低,差异有统计学意义(P<0.05),且观察组均低于对照组,差异有统计学意义(P<0.05)。结论与单纯使用氯沙坦钾相比,采用氯沙坦钾联合前列地尔治疗慢性肾小球肾炎,疗效更显著,患者肾功能改善更明显,炎性因子水平降低,且不增加患者不良反应。

Objective To analyze the effect of losartan potassium combined with alprostadil in the treatment of chronic glomerulonephritis.Methods Ninety-three patients with chronic glomerulonephritis admitted to the hospital from August 2019 to August 2020 were selected as the research objects,and they were divided into two groups by random number table.Both groups were given conventional treatment.On this basis,Losartan potassium was given to the control group(46 cases),and Losartan potassium combined with alprostadil was given to the observation group(47 cases)to compare the efficacy,changes in renal function,and adverse reactions.Results The total curative effect of the control group was 78.26%,and the observation group was 93.62%.Compared between the groups,the observation group was higher,the difference was statistically significant(χ^(2)=4.559,P<0.05);the two groups had 3 renal function indexes[creatinine(Scr),urea nitrogen(BUN),24 h urine protein quantification]after treatment,all decreased,the difference was statistically significant(P<0.05),compared between groups,the observation group was lower,the difference was statistically significant(P<0.05);the total incidence of adverse reactions in the control group was 10.87%and the observation group was 8.51%,there was no significant difference between groups,the difference was statistically significant(χ^(2)=0.001,P>0.05);3 inflammatory factors in the two groups[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],after treatment,the level decreased,the difference was statistically significant(P<0.05),and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Compared with the simple use of Losartan Potassium,the combination of Losartan Potassium and Alprostadil in the treatment of chronic glomerulonephritis has a more significant effect.The renal function of the patient is improved more significantly,the level of inflammatory factors is reduced,and the adverse reactions of the patient are not increased.