胃癌前病变中医证型与Hp感染、胃黏膜病理改变相关性研究

Study on the Correlation between TCM Syndrome Types of Precancerous Lesion of Gastric Cancer,Hp Infection and Pathological Changes of Gastric Mucosa

目的:通过分析胃癌前病变的中医证型分布,以及6种证型与Hp感染和胃黏膜病理改变之间的联系,为中医指导胃癌前病变辨证诊治提供循证医学证据。方法:分析120例胃癌前病变患者的中医证型、Hp感染情况和病理诊断数据,分析胃癌前病变中医证型分布,及其与Hp感染、胃黏膜病理改变的相关关系。结果:6种证型与Hp感染有一定相关性(P<0.05),其中脾胃湿热证感染率最高。腺体萎缩分布比较,经卡方检验,差异具有统计学意义(P<0.05);胃络瘀阻证明显高于其他证型,可以通过证型预判断腺体萎缩是否为阳性。不同证型肠上皮化生、异型增生分布比较,无明显相关性(P>0.05)。结论:胃癌前病变中医证型与Hp感染有相关性,脾胃湿热证感染率最高,胃癌前病变中医证型与胃黏膜萎缩改变有相关性,胃络瘀阻证更容易表现为胃黏膜萎缩。

Objective:By analyzing the distribution of TCM syndrome types of precancerous lesions of gastric cancer,as well as the relationship between 6 syndrome types and Hp infection and gastric mucosal pathological changes,it provides evidence-based medicine evidence for TCM to guide the diagnosis and treatment of precancerous lesions of gastric cancer.Methods:Analyze the TCM syndrome types,Hp infection and pathological diagnosis datas of 120 patients with precancerous lesions of gastric cancer,analyze the distribution of TCM syndrome types of precancerous lesions of gastric cancer,and their correlation with Hp infection and gastric mucosal pathological changes.Results:There was a certain correlation between the 6 types of syndromes and Hp infection(P<0.05),among which the infection rate of spleen and stomach damp-heat syndrome was the highest.The comparison of the distribution of gland atrophy,the difference was statistically significant after Chi-square test(P<0.05).The proof of gastric-collateral stasis is significantly higher than that of other syndromes,and the syndrome can be used to predict whether gland atrophy is positive.There was no significant correlation in the distribution of intestinal metaplasia and dysplasia of different syndrome types(P>0.05).Conclusion:The TCM syndromes of precancerous lesions of gastric cancer are related to Hp infection.The infection rate of spleen and stomach damp-heat syndrome is the highest.The TCM syndromes of precancerous lesions of gastric cancer are correlated with changes in gastric mucosal atrophy.The syndrome of gastric collateral stasis is more likely to manifest as gastric mucosal atrophy.