氧化应激与生殖相关疾病研究进展

Research Progress on Oxidative Stress and Reproductive Related Diseases

活性氧(reactive oxygen species,ROS)是氧与电子反应后的产物,适当的ROS水平和氧化应激平衡对维持生理功能有着重要作用。当ROS产生过多或消除ROS的能力减弱,产生氧化应激(oxidative stress,OS),可导致多种不孕相关疾病。氧化应激参与了多囊卵巢综合征、子宫内膜异位症、复发性流产等多种疾病的发生发展,同时参与疾病的转归。除了参与女性生殖相关疾病,氧化应激也可以降低精液的质量,影响男性的生殖功能。因此就氧化应激在生殖系统相关疾病的发病机制中所发挥的作用进行综述。

Reactive oxygen species(ROS)is the product of the reaction between oxygen and electrons.The appropriate level of ROS and the oxidative stress balance play an important role in maintaining physiological function.When ROS was produced too much or the ability to eliminate ROS was weakened,the increased oxidative stress(OS)could lead to a variety of infertility-related diseases.OS is involved in the occurrence and development of polycystic ovary syndrome,endometriosis,recurrent abortion and other diseases,as well as the prognosis of these diseases.In addition to being involved in female reproductive-related diseases,OS can also reduce semen quality and affect male reproductive function.This article reviews the pathogenesis of oxidative stress and its effect on reproduction-related diseases.