卵泡期长效长方案在体外受精中的应用

Application of Follicular Phase Long-Acting GnRH Agonist Long Protocol in IVF

促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonists,GnRHa)广泛运用于体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)垂体降调节中,并衍生出多种不同控制性促排卵方案,其中卵泡期长效长方案已应用于子宫内膜异位症、卵巢储备正常、多囊卵巢综合征和卵巢低反应等患者的促排卵中,并被证实可改善子宫内膜容受性和胚胎质量,较其他方案有更高的胚胎种植率和临床妊娠率。

Gonadotropin-releasing hormone agonist(GnRHa)has been widely used in the pituitary downregulation of in vitro fertilization and embryo transfer(IVF-ET),in which a variety of the controlled ovarian stimulation protocols were derived.The follicular phase long-acting GnRH agonist long protocol has been gradually used in the patients with endometriosis,polycystic ovary syndrome and poor ovarian response,as well as some patients with normal ovarian reserve in recent years.This protocol has the advantages of higher embryo implantation rate and clinical pregnancy rate by improving endometrial receptivity and embryonic quality,when compared with other protocols.