摘要
Studies on the synthesis of antifungal and anticancer natural product,pseudolaric acid B,have led to the enantioselective synthesis of di-epi-trans-fused[5-7]-bicyclic co re skeleton.The synthesis was achieved in 10 linear steps,which features the Sharpless asymmetric epoxidation,cyanide-opening reaction of epoxide,and intramolecular[5+2]cycloaddition reaction as the key transformations.The stereochemistry was determined by the X-ray crystallographic analysis.
基金
the financial support from the National Natural Science Foundation of China(Nos.21302078,21572089,21732001,21672017)
the Program for Changjiang Scholars and the Innovative Research Team in Universities(PCSIRT:No.IRT_15R28)
the State Key Basic Research Program of the PRC(No.2018YFC0310900)
Shenzhen Science and Technology Innovation Committee(No.JCYJ20180504165454447)
Shenzhen Basic Research Program(No.20180202)
the National Ten Thousand Talent Program(the Leading Talent Tier)。
