摘要
Delivery systems based on nanoparticles(NPs)have shown great potential to reduce side effects and improve the therapeutic efficacy.Herein,we report the one-pot synthesis of poly(ethylene glycol)-mediated zeolitic imidazolate framework-8(ZIF-8)NPs for the co-delivery of an anticancer drug(i.e.,doxorubicin)and a cell penetrating peptide containing histidine and arginine(i.e.,H4 R4)to improve the efficacy of therapeutic delive ry.The cargo-encapsulated ZIF-8 NPs are pH-responsive,which are stable at neutral pH and degradable at acidic pH to release the encapsulated cargos.The released H4 R4 can help for endosome/lysosome escape to enhance the cytotoxicity of the encapsulated drugs.In vivo studies demonstrate that the co-delivery of doxo rubicin and H4 R4 peptides can efficiently inhibit tumor growth without significant side effects.The reported strategy provides a new perspective on the design of drug delivery systems and brings more opportunities for biomedical applications.
基金
supported by the National Natural Science Foundation of China(Nos.21872085 and 21902088)
the Project for Scientific Research Innovation Team of Young Scholar in Colleges and Universities of Shandong Province(No.2020KJC001)。
