丁苯酞联合银杏内酯治疗老年急性脑梗死临床观察

Clinical Observation of Butylphthalide Combined with Ginkgolide in the Treatment of Elderly Patients with Acute Cerebral Infarction

目的探讨丁苯酞联合银杏内酯治疗老年急性脑梗死(ACI)的临床疗效,以及对患者血清同型半胱氨酸(HCY)、血管内皮生长因子(VEGF)和氧化应激指标的影响。方法选取医院2018年至2019年收治的老年ACI患者78例,采用随机数字表法分为对照组和观察组,各39例。两组患者均予常规治疗,并以丁苯酞氯化钠注射液静脉滴注,观察组患者加用银杏内酯注射液静脉滴注。两组均连续治疗2周。结果观察组总有效率为94.87%,显著高于对照组的79.49%(P<0.05);观察组患者治疗后的美国国立卫生研究院卒中量表(NIHSS)、血清HCY、丙二醛(MDA)水平均显著低于对照组,VEGF、谷胱甘肽过氧化物酶(GSH-Px)和血清超氧化物歧化酶(SOD)水平均显著高于对照组(P<0.05)。结论丁苯酞联合银杏内酯治疗老年ACI有一定疗效,能调节患者血清HCY和VEGF的表达水平,改善氧化应激损伤,提高生命质量。

Objective To investigate the clinical efficacy of butylphthalide combined with ginkgolide in the treatment of elderly patients with acute cerebral infarction(ACI)and its effect on serum homocysteine(HCY),vascular endothelial growth factor(VEGF)and oxidative stress indexes.Methods A total of 78 elderly patients with ACI admitted to our hospital from 2018 to 2019 were selected and divided into the control group and the observation group according to the random number table method,39 cases in each group.The patients in the two groups were given routine treatment and intravenous drip of Butylphthalide Sodium Chloride Injection,on this basis,the patients in the observation group were given intravenous drip of Ginkgolide Injection.Both groups were continuously treated for two weeks.Results The total effective rate of the observation group was 94.87%,which was significantly higher than 79.49%of the control group(P<0.05).After treatment,the score of the National Institutes of Health Stroke Scale(NIHSS),the levels of serum HCY and malondialdehyde(MDA)in the observation group were significantly lower than those in the control group,and the levels of VEGF,glutathione peroxidase(GSH-Px)and serum superoxide dismutase(SOD)in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Butylphthalide combined with ginkgolide is effective in the treatment of elderly patients with ACI,which can regulate the expression levels of serum HCY and VEGF,improve oxidative stress injury and the quality of life.