鼻咽淋巴瘤临床特征及其与肿瘤微环境的关系

Clinical characteristic of nasopharyngeal lymphoma and its association with tumor microenvironment

既往文献常将发生于鼻咽部的淋巴瘤归入鼻腔淋巴瘤进行研究和报道,但鼻咽淋巴瘤可能有其独有的临床表现和病理特点,预后与鼻腔淋巴瘤亦存在差异。炎症与肿瘤微环境在肿瘤发生、发展中的作用是近年来肿瘤研究领域的一个热点,这类指标获取容易,且便于动态监测。为此,特将鼻咽淋巴瘤的临床特征、肿瘤微环境和外周血炎症指标与鼻咽淋巴瘤的预后关系予以综述。

The primary nasopharyngeal lymphoma(NPL)has often been classified as the primary nasal lymphoma(NSL)in many previous literatures.However,special characteristics of clinical manifestations and pathology could be found in NPL,and the differences also existed in prognosis between NPL and NSL.More and more research showed that inflammatory and tumor microenvironment might play an important role in the occurrence and progress of malignant tumors.These inflammatory indicators are easy to obtain and convenient for monitoring.Therefore,the clinical characteristics of nasopharyngeal lymphoma,the predicative value of tumor microenvironment and peripheral blood inflammatory indicators for the lymphoma prognosis were reviewed.