电针联合药物治疗慢性非细菌性前列腺炎的疗效观察

Efficacy Observation of Electroacupuncture Combined with Medication for Chronic Nonbacterial Prostatitis

目的观察电针联合药物治疗慢性非细菌性前列腺炎的临床疗效。方法将112例慢性非细菌性前列腺炎患者随机分为对照组与联合组,每组56例。对照组口服盐酸左氧氟沙星片,联合组在对照组治疗的基础上采用电针联合激光治疗。观察两组治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分(包括疼痛不适、排尿、生活质量)、勃起功能国际问卷-5(IIEF-5)评分、最大尿流率、平均尿流率和前列腺按摩液中白细胞计数(EPS-WBC)、白介素(IL)-2、IL-6、肿瘤坏死因子(TNF)-α水平,并比较两组临床疗效。结果联合组显效率和总有效率分别为58.9%、83.9%,明显高于对照组的44.6%、67.9%,差异有统计学意义(P<0.05)。两组治疗前NIH-CPSI评分、IIEF-5评分比较,差异无统计学意义(P>0.05);治疗后以上指标均有改善(P<0.05),联合组在NIH-CPSI疼痛评分及总分、IIEF-5评分优于对照组(P<0.05)。两组治疗前最大尿流率、平均尿流率比较,差异无统计学意义(P>0.05);治疗后以上指标均有改善(P<0.05),联合组最大尿流率优于对照组(P<0.05)。两组治疗前EPS-WBC计数及IL-2、IL-6、TNF-α比较,差异无统计学意义(P>0.05);治疗后两组上述指标均明显下降(P<0.05),联合组优于对照组(P<0.05)。结论电针联合药物治疗慢性非细菌性前列腺炎的疗效显著,能明显改善患者的临床症状,增加尿流率,降低炎性因子水平。

Objective To observe the clinical efficacy of electroacupuncture(EA)combined with medication in treating chronic nonbacterial prostatitis.Method A total of 112 patients with chronic nonbacterial prostatitis were randomized into a control group and a joint group,with 56 cases in each group.The control group was intervened by oral administration of Levofloxacin hydrochloride,while the joint group was given additional EA and laser treatment.Before and after treatment,the scores of National Institute of Health Chronic Prostatitis Symptom Index(NIH-CPSI,including pain and discomfort,micturition and quality of life)and International Index of Erectile Function-5(IIEF-5),maximal urinary flow rate,mean urinary flow rate,the count of white blood cells in expressed prostatic secretion(EPS-WBC),and the levels of interleukin(IL)-2,IL-6 and tumor necrosis factor(TNF)-αwere observed in the two groups.Clinical efficacy was also compared.Result The markedly effective rate was 58.9%and total effective rate was 83.9%in the joint group,significantly higher than 44.6%and 67.9%in the control group(P<0.05).There were no significant differences in the NIH-CPSI and IIEF-5 scores between the two groups prior to treatment(P>0.05);these two measurements were improved after treatment(P<0.05),and the joint group won out over the control group comparing the score of pain and general score of NIH-CPSI and IIEF-5 score(P<0.05).There were no significant differences in the maximal urinary flow rate and mean urinary flow rate between the two groups before treatment(P>0.05);these parameters showed improvement after treatment(P<0.05),and the joint group was superior to the control group comparing the maximal urinary flow rate(P<0.05).Prior to treatment,the differences in the count of EPS-WBC,IL-2,IL-6 and TNF-αwere statistically insignificant between the two groups(P>0.05);after treatment,these indicators decreased notably in both groups(P<0.05),and the joint group was superior to the control group(P<0.05).Conclusion EA combined with medication can produce significant efficacy in treating chronic nonbacterial prostatitis;it can notably improve the clinical symptoms,increase urinary flow rate and down-regulate the levels of inflammatory factors.