火针对多囊卵巢综合征不孕症患者性激素、排卵及子宫内膜容受性的影响

Effect of Fire Needling on Sex Hormones,Ovulation and Endometrial Receptivity in PCOS Patients with Infertility

目的观察火针治疗多囊卵巢综合征(PCOS)不孕症临床疗效及其对性激素、排卵及子宫内膜容受性的影响。方法选取124例PCOS不孕症患者,随机分为常规组和研究组,每组62例。常规组予以常规治疗,研究组在常规组治疗基础上采用火针治疗。比较两组治疗前后症状评分变化,治疗前后血清性激素水平变化[促卵泡激素(FSH)、雌二醇(E2)、孕酮(P)],子宫内膜容受性变化[子宫内膜厚度(ET)、子宫螺旋动脉血流搏动指数(PI)、子宫螺旋动脉血流阻力指数(RI)],并比较两组临床疗效及不良反应情况。结果治疗后,两组主症、次症、总症状评分均低于治疗前,且研究组均低于常规组,差异均有统计学意义(P<0.05)。治疗后,两组血清FSH、E2、P水平均高于治疗前,且研究组均高于常规组,差异均有统计学意义(P<0.05)。两组治疗后ET均高于治疗前,且研究组高于常规组;PI和RI均低于治疗前,且研究组均低于常规组,差异均有统计学意义(P<0.05)。两组临床疗效比较差异有统计学意义(P<0.05);研究组总有效率高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在常规治疗基础上,火针治疗PCOS不孕症可减轻症状、调节性激素水平,还可改善子宫内膜容受性。

Objective To investigate the clinical efficacy of fire needling for infertility and its effect on sex hormones,ovulation and endometrial receptivity in polycystic ovarian syndrome(PCOS).Method One hundred and twenty-four PCOS patients with infertility were enrolled and randomized to conventional and study groups,with 62 cases in each group.The conventional group received conventional treatment and the study group,fire needling in addition.The symptom scores,serum sex hormone[follicle-stimulating hormone(FSH),estradiol(E2)and progesterone(P)]levels and endometrial receptivity endometrial thickness(ET),uterine spiral artery blood flow pulsation index(PI)and uterine spiral artery blood flow resistance index(RI)were compared between the two groups before and after treatment.The clinical therapeutic effects and adverse reactions were also compared between the two groups.Result After treatment,the primary symptom score,the secondary symptom score and the total symptom score decreased in the two groups compared with before and were lower in the study group than in the conventional group with statistically significant differences(P<0.05).After treatment,serum sex hormone FSH,E2 and P increased in the two groups compared with before and were higher in the study group than in the conventional group with statistically significant differences(P<0.05).After treatment,ET increased in the two groups compared with before and was higher in the study group than in the conventional group and PI and RI decreased in the two groups compared with before and were lower in the study group than in the conventional group with statistically significant differences(P<0.05).There was a statistically significant difference in the clinical therapeutic effect between the two groups(P<0.05).The total efficacy rate was higher in the study group than in the conventional group with a statistically significant difference(P<0.05).There was no statistically significant difference in the adverse reaction incidence between the two groups(P>0.05).Conclusion On the basis of conventional treatment,fire needling can relieve the symptoms,regulate sex hormone levels and improve endometrial receptivity in treating PCOS infertility.