m6A-RNA甲基化在弥漫大B细胞淋巴瘤中的研究进展

Research Progress of m6A-RNA Methylation in Diffuse Large B Cell Lymphoma

弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)是非霍奇金淋巴瘤(non-hodgkin lymphoma,NHL)中最常见的亚型,其发病机制错综复杂,至今尚未被充分阐明。因其具有较大的异质性导致患者预后差,针对DLBCL的治疗面临着巨大的挑战。近年来,表观遗传修饰成为DLBCL发病机制的研究热点。越来越多的研究表明,m6A-RNA甲基化可动态调节DLBCL的发生发展。该文就m6A-RNA甲基化修饰在DLBCL中的研究进展作一综述,从表观遗传学的角度为DLBCL的早期诊断、治疗以及预后提供新策略。

Although DLBCL(diffuse large B-cell lymphoma)is the most frequent subtype of non-hodgkin lymphoma,its complex pathogenesis is still far from clarity.Because of its heterogeneity,the poor prognosis of DLBCL challenges standard therapy regimen nowadays.Recently,epigenetic modification becomes a hot spot in DLBCL.Lots of researches demonstrated that m6A-RNA methylation could dynamically modulate the incidence and development of DLBCL.This paper reviews the research progress of m6A-RNA methylation in DLBCL,and provides a new strategy for the early diagnosis,treatment and prognosis of DLBCL.