补肾调经汤联合孕三烯酮治疗子宫内膜异位症的效果及对免疫功能的影响

Effect of Bushen Tiaojing Decoction(补肾调经汤)combined with Gestrinone on Endometriosis and Its Influence on Immune Function

目的探讨补肾调经汤联合孕三烯酮治疗子宫内膜异位症的效果及对免疫功能的影响。方法经珠海市妇幼保健院伦理委员会批准后将2018年11月—2020年3月94例医院收治的子宫内膜异位症患者按照随机数字表法分为2组,对照组47例予以孕三烯酮治疗,研究组47例予以补肾调经汤联合孕三烯酮治疗,两组患者均治疗3个月时间。比较两组患者临床疗效以及治疗前后T淋巴细胞水平(CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8))以及血清糖类抗原125(CA125)、抗子宫内膜抗体(EMAb)水平。结果研究组临床总有效率高于对照组(P<0.05)。两组患者治疗前CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)水平比较差异无统计学意义(P>0.05),治疗后两组CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)水平均高于治疗前,且研究组高于对照组。两组对比,差异具有统计学意义(P<0.05)。两组患者治疗前血清CA125和EMAb水平比较差异无统计学意义(P>0.05),治疗后两组血清CA125和EMAb水平均低于治疗前,且研究组低于对照组,两组对比,差异具有统计学意义(P<0.05)。结论补肾调经汤联合孕三烯酮治疗子宫内膜异位症疗效确切,可显著提高机体免疫力,降低CA125和EMAb水平,值得推广应用。

Objective To investigate the effect of Bushen Tiaojing decoction(补肾调经汤)combined with gestrinone in the treatment of endometriosis and its influence on immune function. Methods with the approval of the ethics committee of Zhuhai maternal and child health care hospital, 94 patients with endometriosis admitted to our hospital from November 2018 to March 2020 were randomly divided into two groups, 47 cases in the control group were treated with gestrinone, and 47 cases in the study group were treated with Bushen Tiaojing decoction combined with gestrinone. Both groups were intervened for 3 months. The clinical efficacy, T lymphocyte levels(CD^(+)_(3), CD^(+)_(4), CD^(+)_(4)/CD^(+)_(8)) and serum carbohydrate antigen 125(CA125), anti endometrial antibody(EMAb) levels before and after intervention were compared between the two groups. Results the total effective rate of the study group was higher than that of the control group(P < 0.05). The difference between the two groups was statistically significant. There was no significant difference in the levels of CD^(+)_(3), CD^(+)_(4), CD^(+)_(4)/CD^(+)_(8) between the two groups before intervention(P> 0.05). After intervention, the levels of CD^(+)_(3), CD^(+)_(4), CD^(+)_(4)/CD^(+)_(8) in the two groups were higher than before intervention, and the study group was higher than the control group. The difference between the two groups was statistically significant(P< 0.05). There was no significant difference in serum CA125 and EMAb levels between the two groups before the intervention(P > 0.05). After the intervention, the serum CA125 and EMAb levels of the two groups were lower than before the intervention, and the study group was lower than the control group, the difference was statistically significant(P< 0.05). Conclusion Bushen Tiaojing decoction combined with gestrinone is effective in the treatment of endometriosis. It can significantly improve the body’s immunity and reduce the levels of CA125 and EMAb, which is worthy of clinical application.