NLRP3炎症小体/白介素-1β信号通路与动脉粥样硬化及活血解毒中药干预研究进展

Research Progress of NLRP3 inflammosome/IL-1β Signaling Pathway, Atherosclerosis and Intervention of Traditional Chinese Medicine for Promoting Blood Circulation and Detoxification

动脉粥样硬化(atherosclerosis, AS)是一种发生于动脉血管壁的慢性炎症性疾病,NLRP3炎症小体/IL-1β信号通路介导的炎症反应在AS的发生发展中扮演者重要角色。活血解毒是中医药防治AS的创新性治法,近年研究表明,活血解毒方药可通过调控NLRP3炎症小体/IL-1β信号通路发挥抗炎治疗AS的作用,从NLRP3炎症小体/IL-1β信号通路介导的炎症反应为切入点开展活血解毒方药抗AS的机制研究,有望为动脉粥样硬化性心血管疾病的中医药防治提供新策略。

Atherosclerosis(AS) is a chronic inflammatory disease occurring in the arterial wall. NLRP3 inflammosome/IL-1β signaling pathway plays an important role in the development of AS. Promoting blood circulation and detoxifying method is an innovative treatment of traditional Chinese medicine in the prevention and treatment of AS. In recent years, studies have shown that promoting blood circulation and detoxifying method can play an anti-inflammatory role in treating AS by regulating the NLRP3 inflammosome/IL-1β signal pathway. The research on the mechanism of promoting blood circulation and detoxifying method against AS from the inflammatory response mediated by NLRP3 inflammosome/IL-1β signaling pathway is expected to provide a new strategy for the prevention and treatment of atherosclerotic cardiovascular disease.