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通肺平哮汤对支气管哮喘急性发作期肺功能及炎症因子的影响 被引量:11

Effects of Tongfei Pingxiao Decoction(通肺平哮汤)on Lung Function and Inflammatory Factors in Children with Acute Attack of Bronchial Asthma
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摘要 目的探讨通肺平哮汤对支气管哮喘急性发作期患儿肺功能及炎症因子的影响。方法选取诊治的支气管哮喘急性发作期患儿80例,随机分为对照组与观察组,每组40例,两组患儿均给予常规的西医药物治疗,观察组同时给予通肺平哮汤辅助治疗。观察两组治疗后咳嗽、咳痰、喘息、胸闷、哮鸣音消失时间,治疗前后肺功能指标最高呼气流量(PEF)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量的比值(FEV1/FVC)变化,血清白介素-4(IL-4)、干扰素-γ(INF-γ)、白三烯(LT)及血小板激活因子(PAF)变化。结果观察组咳嗽、咳痰、喘息、胸闷、哮鸣音消失时间明显短于对照组,差异有统计学意义(P<0.05);两组治疗前PEF、FEV1、FVC、FEV1/FVC差异无统计学意义(P>0.05),治疗后较治疗前升高(P<0.05),且观察组升高程度大于对照组(P<0.05);两组治疗前IL-4、INF-γ、LT及PAF比较差异无统计学意义(P>0.05),治疗后IL-4、LT及PAF较治疗前下降(P<0.05),且观察组下降程度大于对照组(P<0.05),INF-γ较治疗前升高(P<0.05),且观察组升高幅度大于对照组(P<0.05);对照组治疗总有效率为77.50%(31/40),低于观察组95.00%(38/40)(P<0.05)。结论通肺平哮汤用于支气管哮喘急性发作期患儿的辅助治疗有助于肺功能改善,减轻炎症反应,缩短症状改善时间。 Objective To investigate the effects of Tongfei Pingxiao Decoction(通肺平哮汤) on lung function and inflammatory factors in children with acute attack of bronchial asthma. Methods We collected 80 cases of children with acute attack of bronchial asthma. The patients were randomly divided into control group and observation group, 40 cases in each group. The two groups received routine western medicine treatment. The observation group at the same time added Tongfei Pingxiao Decoction adjuvant treatment. We observed the disappearance time of cough, sputum, wheezing and chest tightness after treatment in the two groups, PEF and FEV1, FVC, FEV1/FVC,IL-4, INF-γ,LT and PAF before and after treatment. Results The disappearance time of cough, sputum, wheezing and chest tightness after treatment of the observation group was shorter than that of the control group(P<0.05). There was no statistically significant difference in PEF, FEV1, FVC or FEV1/FVC between the two groups before treatment(P>0.05) and those indexes were increased after treatment(P<0.05). The increase amplitude of the observation group was greater than that of the control group(P<0.05). There was no statistically significant difference in IL-4,INF-γ,LT or PAF between the two groups before treatment(P>0.05). IL-4, LT and PAF were decreased after treatment compared with those before treatment(P<0.05) and the degree of decline in the observation group was greater than that in the control group(P<0.05). INF-γ was higher than that before treatment(P<0.05). The increase amplitude of the observation group was greater than that of the control group(P<0.05). The total effective rate of the control group(77.50%,31/40) was lower than that of the observation group(95.00%,38/40)(P<0.05). Conclusion Tongfei Pingxiao Decoction is helpful for the improvement of lung function in children with acute attack of bronchial asthma, reduce inflammation and shorten symptom improvement time.
作者 李冰 孙晓敏 张广超 李夏 LI Bing;SUN Xiaomin;ZHANG Guangchao;LI Xia(Childrens Hospital Affiliated to Zhengzhou University,Childrens Hospital of Henan Province,Zhengzhou Childrens Hospital,Zhengzhou 450007,Henan,China)
出处 《中华中医药学刊》 CAS 北大核心 2021年第8期125-127,共3页 Chinese Archives of Traditional Chinese Medicine
基金 国家中医药管理局中医药科学技术研究专项(2018ZX791) 河南省医学科技攻关计划(2018020647)。
关键词 通肺平哮汤 支气管哮喘 急性发作期 肺功能 炎症因子 Tongfei Pingxiao Decoction(通肺平哮汤) bron(.hial asthma acute attack lung function inflammatory factors
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