宣肺补脾法结合维生素AD滴丸对小儿反复呼吸道感染的治疗效果及对免疫力的影响研究

Study on Therapeutic Effect of Dispersing Lung and Invigorating Spleen Method Combined with Vitamin AD Dropping Pills on Children with Repeated Respiratory Tract Infection and Its Influence on Immunity

目的评价宣肺补脾法结合维生素AD滴丸对小儿反复呼吸道感染的治疗效果及对免疫力的影响。方法选择2017年3月—2019年12月医院收治的反复呼吸道感染患儿300例,依据随机对照法将患者分为研究组和对照组,每组150例。给予对照组患儿退热、化痰、止咳,根据感染源给予抗感染、抗病毒对症处理,口服匹多莫德口服液治疗。1瓶/次,2次/d。研究组在对照组治疗的基础上,口服宣肺补脾汤结合维生素AD滴丸辅助治疗。两组患儿均治疗2个月。比较两组治疗前后中医证候积分、比较两组治疗疗效、比较两组临床症状消失时间和免疫功能指标水平变化。结果研究结果显示,研究组治疗疗效高于对照组(P<0.05);研究组治疗后咳嗽、咳痰、倦怠少言、大便溏薄、面色少华、恶风等中医证候积分低于对照组(P<0.05);研究组患儿咳嗽咳痰、鼻涕鼻塞、咽喉充血、肺部罗音症状消失时间均较对照组短(P<0.05);研究组治疗后免疫功能指标CD+3、CD+4和CD+4/CD+8水平高于对照组,CD+8水平低于对照组(P<0.05)。结论宣肺补脾法结合维生素AD治疗小儿反复呼吸道感染,可有效的改善患儿的临床症状,缩短治疗时间,提高患儿免疫功能,值得临床推广应用。

Objective To evaluate the therapeutic effect of dispersing lung and invigorating spleen method combined with vitamin AD dropping pills on children with recurrent respiratory tract infection and its influence on immunity. Methods A total of 300 children with recurrent respiratory tract infection admitted to our hospital from March 2017 to December 2019 were selected and divided into study group and control group according to the randomized control method, with 150 cases in each group. The control group was given antipyretic, anti-infection and antiviral treatment according to the source of infection and Pidotimod Oral Liquid, 1 bottle once, twice a day. On the basis of the treatment in the control group, the treatment group was assisted by oral Xuanfei Bupi Decoction combined with vitamin AD dropping pills. Both groups were treated for 2 months. The scores of TCM syndromes before and after treatment, the therapeutic effect, the time of disappearance of clinical symptoms and the level of immune function of the two groups were compared. Results The results showed that the therapeutic effect of the study group was higher than that of the control group(P<0.05). After treatment, the score of TCM syndromes in the study group was lower than that in the control group(P<0.05). In the study group, the disappearance time of cough and sputum, nasal congestion, throat congestion and lung rhonchus was shorter than that in the control group(P<0.05). The levels of CD+3, CD+4 and CD+4/CD+8 in the study group were higher than those in the control group, while the levels of CD+8 were lower than those in the control group(P<0.05). Conclusion The combination of dispersing lung and invigorating spleen method combined with vitamin AD dropping pills can effectively improve the clinical symptoms, shorten the treatment time, and improve the immune function of children with repeated respiratory tract infections, worthy of clinical application.