乙二胺四乙酸对SLC30A溶质转运家族部分成员影响的研究进展

Research Progress on the Effect of Ethylenediaminetetraacetic Acid on Some Members of the SLC30A Solute Transport Family

乙二胺四乙酸(EDTA)是一种能与Mg^(2+)、Ca^(2+)、Mn^(2+)、Fe^(2+)等二价金属离子结合的螯合剂。由于多数核酸酶类和有些蛋白酶类的作用需要Mg^(2+),故常用做核酸酶、蛋白酶的抑制剂;也可用于去除重金属离子对酶的抑制作用。锌作为一种微量营养元素,参与到多种结构蛋白和功能酶的合成与分泌中,是保持良好的内环境所必需的矿物质。锌转运蛋白(Zn T)负责将锌保持在不引起毒性的可控浓度范围内。Zn Ts在细胞膜到细胞器均有表达,其主要的作用是将锌从胞浆运送到细胞外和转运到细胞器或囊泡中。多数锌转运蛋白在细胞中的表达水平取决于锌的浓度和不同的生理环境,病理条件下Zn Ts的表达变化可以在一定程度上揭示疾病发展中的内在机制。这篇文章的目的是提供有关于当EDTA作为锌离子拮抗剂作用时与Zn Ts锌转运蛋白和健康问题间联系的信息。

Ethylenediaminetetraacetic acid(EDTA) is a chelating agent that can combine with divalent metal ions such as Mg^(2+), Ca^(2+), Mn^(2+), Fe^(2+). Since most nucleases and some proteases require Mg^(2+) for their action, they are often used as inhibitors of nucleases and proteases;they can also be used to remove the inhibitory effects of heavy metal ions on enzymes. As a micronutrient element, zinc participates in the synthesis and secretion of a variety of structural proteins and functional enzymes. It is a mineral necessary to maintain a good internal environment. Zinc transporter(Zn T) is responsible for keeping zinc within a controllable concentration range that does not cause toxicity. Zn Ts are expressed from the cell membrane to the organelles, and their main function is to transport zinc from the cytoplasm to the outside of the cell and to the organelle or vesicle. The expression level of most zinc transporters in cells depends on the concentration of zinc and different physiological environments. The expression changes of Zn Ts under pathological conditions can reveal the internal mechanism of disease development to a certain extent. The purpose of this article is to provide information on the link between Zn Ts zinc transporter and health problems when EDTA acts as a zinc ion antagonist.