期刊文献+

奥沙利铂联合用药致结直肠癌病人恶心、呕吐的危险因素分析 被引量:3

Analysis of risk factors of nausea and vomiting in patients with colorectal cancer caused by oxaliplatin combined use
下载PDF
导出
摘要 目的:探讨接受奥沙利铂联合用药治疗的结直肠癌病人使用标准的止吐药物(5-羟色胺3受体拮抗剂+地塞米松)后出现化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting,CINV)的危险因素分析。方法:选取2020年1月—2020年6月我院收治的339例结直肠癌化疗病人,所有病人均行含奥沙利铂联合用药化疗方案,并接受2种止吐药物。采用美国国立癌症研究所常见不良反应事件术语评价标准(national cancer institute′s common terminology criteria for adverse event,NCI-CTCAE)4.0版评估病人开始化疗后连续5 d的恶心、呕吐情况。结果:在化疗过程中恶心的发生率为35.7%,呕吐的发生率为26.0%。单因素分析结果显示,CINV与年龄、性别和吸烟有关(P<0.05),多因素分析表明低龄、女性和吸烟均是CINV的独立危险因素(P<0.05)。结论:即使使用标准止吐药物,奥沙利铂引起CINV的发生率仍较高,对高危人群需要采取积极的管理措施以降低CINV的发生。
作者 林丽丽 黄国兴 刘颖 林振孟 LIN Lili;HUANG Guoxing;LIU Ying;LIN Zhenmeng(Fujian Medical University Cancer Hospital(Fujian Cancer Hospital),Fujian 350014 China)
出处 《循证护理》 2021年第11期1501-1504,共4页 Chinese Evidence-Based Nursing
基金 2018年福建医科大学启航基金项目,编号:2018QH1231
关键词 奥沙利铂 结直肠癌 恶心 呕吐 危险因素 护理 oxaliplatin colorectal cancer nausea vomiting risk factors nursing
  • 相关文献

参考文献2

二级参考文献14

  • 1Molassiotis A, Saunders M P,Valle J,et al.A prospective observational study of chemotherapy related nausea and vomiting in routine practice in a UK cancer centre[J]. Support Care Cancer,2008,16(2) : 201-208.
  • 2Molassiotis A, Yam B M, Yung H, et al. Pretreatment factors predicting the development of ostchemotherapy nausea and vomiting in Chinese breast cancer patients [J].Support Care Cancer,2002,10(2) : 139-145.
  • 3Pirri C, Katris P, Trotter J, et al.Risk factors at pretreat- ment predicting treatment-induced nausea and vomiting in Australian cancer patients A prospective, longitudi- nal,observational study[J].Support Care Cancer, 2011,19(10):1549-1563.
  • 4Hesketh P J, Aapro M,Street J C, et al.Evaluation of risk factors predictive of nausea and vomiting with current standard-ofLcare antiemetic treatment: Analysis of two phase Ⅲ trials of aprepitant in patients receiving cispla- tin-based chemotherapy[J]. Support Care Cancer, 2010, 18(9) : 1171-1177.
  • 5Dranitsaris G, Bouganim N, Milano C, et al. Prospective validation of a prediction tool for identifying patients at high risk for chemotherapy-induced nausea and vomi- ting[J].J Support Oncol, 2013,11 (1) : 14-21.
  • 6Molassiotis A, Stamataki Z, Kontopantelis E. Develop- ment and preliminary validation of a risk prediction mod- el for chemotherapy-related nausea and vomiting [J]. Support Care in Cancer,2013,21(10):2759.
  • 7Haniadka R,Rajeev A G,Palatty P L,et al.Zingiber offi- cinale(ginger) as an anti-emetic in cancer chemotherapy: A review[J].J Altern Complement Med, 2012,18 (5) : 440-444.
  • 8Garcia M K, McQuade J, Haddad R.Systematic review of acupuncture in cancer care: A synthesis of the evidence [J].J Clin Oncol,2013,31(7) :952-960.
  • 9万永慧,毛宗福,邱艳茹.音乐疗法对癌症病人焦虑、抑郁及疼痛的影响[J].护理研究(上旬版),2009(5):1172-1175. 被引量:82
  • 10赵艳,田丽,秦保玲.异位妊娠相关因素的多元Logistic回归分析及其预防[J].现代诊断与治疗,2011,22(3):181-183. 被引量:13

共引文献28

同被引文献27

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部