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奥沙利铂联合用药致结直肠癌病人恶心、呕吐的危险因素分析 被引量:3

Analysis of risk factors of nausea and vomiting in patients with colorectal cancer caused by oxaliplatin combined use
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摘要 目的:探讨接受奥沙利铂联合用药治疗的结直肠癌病人使用标准的止吐药物(5-羟色胺3受体拮抗剂+地塞米松)后出现化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting,CINV)的危险因素分析。方法:选取2020年1月—2020年6月我院收治的339例结直肠癌化疗病人,所有病人均行含奥沙利铂联合用药化疗方案,并接受2种止吐药物。采用美国国立癌症研究所常见不良反应事件术语评价标准(national cancer institute′s common terminology criteria for adverse event,NCI-CTCAE)4.0版评估病人开始化疗后连续5 d的恶心、呕吐情况。结果:在化疗过程中恶心的发生率为35.7%,呕吐的发生率为26.0%。单因素分析结果显示,CINV与年龄、性别和吸烟有关(P<0.05),多因素分析表明低龄、女性和吸烟均是CINV的独立危险因素(P<0.05)。结论:即使使用标准止吐药物,奥沙利铂引起CINV的发生率仍较高,对高危人群需要采取积极的管理措施以降低CINV的发生。
作者 林丽丽 黄国兴 刘颖 林振孟 LIN Lili;HUANG Guoxing;LIU Ying;LIN Zhenmeng(Fujian Medical University Cancer Hospital(Fujian Cancer Hospital),Fujian 350014 China)
出处 《循证护理》 2021年第11期1501-1504,共4页 Chinese Evidence-Based Nursing
基金 2018年福建医科大学启航基金项目,编号:2018QH1231
关键词 奥沙利铂 结直肠癌 恶心 呕吐 危险因素 护理 oxaliplatin colorectal cancer nausea vomiting risk factors nursing
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